Journal Article10.1016/J.BIOCEL.2017.07.009
From insulin synthesis to secretion: Alternative splicing of type 2 ryanodine receptor gene is essential for insulin secretion in pancreatic β cells.
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TL;DR: The islet-type ryanodine receptor mRNA caused a greater increase in the Ca2+ release by caffeine when expressed in HEK293 cells pre-treated with cyclic ADP-ribose, suggesting that the novel ryanODine receptor is an intracellular target for the CD38-cyclic ADp- ribose signal system in mammalian cells.
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About: This article is published in The International Journal of Biochemistry & Cell Biology. The article was published on 01 Oct 2017. The article focuses on the topics: Ryanodine receptor & Ryanodine receptor 2.
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Citations
Essential Cysteine Residues for Cyclic ADP-ribose Synthesis and
Akira TohgoS,Shin Takasawa,Naoya Noguchi,Tetsuhiko Koguma,Koji Nata,Takako Sugimoto,Yasuhito Furuya,Hideto Yonekura,Hiroshi Okamotos +8 more
- 01 Jan 1994
TL;DR: Takasawa, S., Nata, K., Yonekura, H., and Okamoto, H. (1993) Science 259, (Yamashina, I., ed) p 218, Bridge Ltd., Nagoya, Japan as mentioned in this paper.
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Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD
Jureepon Roboon,Tsuyoshi Hattori,Hiroshi Ishii,Mika Takarada-Iemata,Dinh Thi Nguyen,Collin D. Heer,Denis O’Meally,Charles Brenner,Yasuhiko Yamamoto,Hiroshi Okamoto,Hiroshi Okamoto,Haruhiro Higashida,Osamu Hori +12 more
TL;DR: In this article, the authors investigated the effect of CD38 deletion and inhibition and supplementation of NAD+ on lipopolysaccharide (LPS)-induced neuroinflammation in mice.
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Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases.
TL;DR: How IH influences pulmonary circulation to cause pulmonary hypertension during sleep in association with sleep state-specific change in OSA is demonstrated and the effects of IH on insulin secretion and insulin resistance are elucidated by using an in vitro chamber system that can mimic and manipulate IH.
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Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD).
TL;DR: The basic metabolism of NGD and NHD is revealed and they serve as coenzymes for alcohol dehydrogenase (ADH) in vitro, although their affinity is much lower than that of NAD.
CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus.
Thom P. Nelissen,Rosemary A. Bamford,Shiro Tochitani,Kamuran Akkus,Aurimas Kudzinskas,Kenichiro Yokoi,Hiroshi Okamoto,Yasuhiko Yamamoto,J. Peter H. Burbach,Hideo Matsuzaki,Hideo Matsuzaki,Asami Oguro-Ando +11 more
TL;DR: The data suggest that CD38 is implicated in appropriate development of brain regions important for social behavior in mice with known behavioral deficits, and abnormalities in the number of neurons and neuronal morphology in the visual cortex and dentate gyrus are found.
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References
A catalogue of splice junction sequences
TL;DR: The sequence CAAG/GTAGAGT was found to be a consensus of 139 exon-intron boundaries (or donor sequences) and (TC)nNCTAG/G was found of 130 intron-exon boundaries ( or acceptor sequences).
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Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas
Paul E. Lacy,Mery Kostianovsky +1 more
TL;DR: A simple method for the isolation of intact islets from the normal rat pancreas is described, based upon disruption of the acinar parenchyma by injecting Hanks solution into the pancreatic duct system followed by incubation of the Pancreas in collagenase.
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Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells.
TL;DR: Using cell-attached membrane patches from isolated rat pancreatic β-cells, this is the first report of a potassium channel whose activity is modulated by glucose, and which may couple metabolic and ionic events involved in the secretion of insulin.
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Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)
Natascia Tiso,Dietrich A. Stephan,Andrea Nava,Alessia Bagattin,Joseph M. Devaney,Fabio Stanchi,Gaelle Larderet,Bhoomi Brahmbhatt,Kevin M. Brown,Barbara Bauce,Michela Muriago,Cristina Basso,Gaetano Thiene,Gian Antonio Danieli,Alessandra Rampazzo +14 more
TL;DR: The detection of RyR2 mutations causing ARVD2 opens the way to pre-symptomatic detection of carriers of the disease in childhood, thus enabling early monitoring and treatment.
Calcium induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres.
TL;DR: The repeated contractions which can be observed in skinned fibres in appropriate concentrations of caffeine, Ca2+ and chelating agent suggest that calcium release is a regenerative process in which calcium itself causes the release of calcium from the reticulum.
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