From endoplasmic-reticulum stress to the inflammatory response
Kezhong Zhang,Randal J. Kaufman +1 more
TL;DR: New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases.
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Abstract: The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding, but it also has an important role in sensing cellular stress. Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response. New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases. The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation.
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Melatonin treatment reduces endoplasmic reticulum stress and modulates the unfolded protein response in rabbits with lethal fulminant hepatitis of viral origin.
María J. Tuñón,Beatriz San-Miguel,Irene Crespo,Almudena Laliena,Daniela Vallejo,Marcelino Álvarez,Jesús Prieto,Javier González-Gallego +7 more
TL;DR: Data obtained provide evidence that in rabbits with experimental infection by RHDV, reduction in apoptotic liver damage by melatonin is associated with attenuation of ER stress through a modulation of the three arms of UPR signaling and further support a potential hepatoprotective role of melatonin in FHF.
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Interplay between the unfolded protein response and reactive oxygen species: a dynamic duo.
TL;DR: In this paper, a review aims to establish a connection between ER stress, UPR, and reactive oxygen species (ROS), which remains an unexplored topic in plants, focusing on mechanisms of ROS production originating from ER stress and the interaction of ER stress with other organellar ROS signalling pathways such as of the mitochondria and chloroplasts.
Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation
Huimin Yan,Hui-fang Zhou,Ying Hu,Christine T.N. Pham +3 more
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TL;DR: Findings establish a central role for autophagy in inflammatory arthritis and argue that Autophagy modulators such as metformin may represent potential therapeutic agents for the treatment of RA.
Endoplasmic Reticulum Stress Induced by Surfactant Protein C BRICHOS Mutants Promotes Proinflammatory Signaling by Epithelial Cells
TL;DR: The results support the role of JNK signaling in mediating SP-C BRICHOS-induced cytokine release, and provide a link between SP- C BRichOS mutants and proinflammatory cytokine signaling.
Endoplasmic reticulum stress and unfolded protein response in inflammatory bowel disease.
TL;DR: With the increased understanding of ER stress in inflammatory bowel disease pathogenesis, it is now possible to develop novel therapies to improve ER protein-folding homeostasis and target-specific UPR pathways in cells residing in the intestinal mucosa.
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