From endoplasmic-reticulum stress to the inflammatory response
Kezhong Zhang,Randal J. Kaufman +1 more
TL;DR: New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases.
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Abstract: The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding, but it also has an important role in sensing cellular stress. Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response. New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases. The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation.
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Citations
Estrogen Receptor and the Unfolded Protein Response: Double-Edged Swords in Therapy for Estrogen Receptor-Positive Breast Cancer
Ping Fan,V. Craig Jordan +1 more
TL;DR: In this paper , the authors showed that ERα and associated UPR are double-edged swords in therapy for ER-positive breast cancer, depending on the duration and intensity of UPR stress.
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Chronic Alcohol Consumption Results in Greater Damage to the Pancreas Than to the Liver in the Rats.
Seong Su Lee,Oak Kee Hong,Anes Ju,Myung-Jun Kim,Bong-Jo Kim,Sung-Rae Kim,Won Ho Kim,Nam H. Cho,Moo-Il Kang,Sung-Koo Kang,Daijin Kim,Soon Jib Yoo +11 more
TL;DR: The results indicate that chronic alcohol consumption increased the risk of diabetes in prediabetic and early diabetic OLETF rats; the pancreas was more susceptible to damage than was the liver in the early diabetic stages, and the adaptive and proapoptotic pathway of ER stress may play key roles in the development and progression of diabetes affected by chronic alcohol ingestion.
Evaluating the dietary taurine requirement of hybrid striped bass, (Morone chrysops x M. saxatilis)
Blaine Suehs,Delbert M. Gatlin +1 more
TL;DR: Diets containing increment levels of taurine were determined to show no significant differences in terms of weight gain, feed efficiency, whole-body composition, hepatosomatic index (HSI), intraperitoneal fat ratio (IPF ratio), or muscle yield, however, hybrid striped bass fed the methionine-deficient diets had significantly different growth performance, health, and body composition.
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Role of Endoplasmic Reticulum Stress in Otitis Media.
H. S. Zhao,H. S. Zhao,Yanfei Wang,Bo Li,Tihua Zheng,Xiuzhen Liu,Bo Hua Hu,Juan Che,Tong Zhao,Jun Chen,Maria Hatzoglou,Xiaolin Zhang,Zhaomin Fan,Qingyin Zheng +13 more
TL;DR: It is proposed that ER stress plays a critical role in inflammation and cell death, leading to the development of OM and points to ER stress inhibition as a potential therapeutic approach for the prevention of OM.
Contribution of long-chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells - induction of MDSC by lipid vesicles (liposome).
Yoichiro Yoshida,Tsunehisa Nagamori,Emi Ishibazawa,Hiroya Kobayashi,Tomoko Kure,Hiromi Sakai,Daisuke Takahashi,Mitsuhiro Fujihara,Hiroshi Azuma +8 more
TL;DR: Investigating whether immunosuppression induction is an immunopharmacological action specific to this pegylated liposome, or not found it not to be so, found B7-H3+ macrophages were positive for iNOS and various liposomes with different long chain fatty acids induced T-cell suppression when accumulated in the spleen.
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