Frequency—response analysis of central vestibular unit activity resulting from rotational stimulation of the semicircular canals
G. Melvill Jones,J. H. Milsum +1 more
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TL;DR: The neural response of semicircular canal‐dependent units in the vestibular nuclei of cats has been examined over a frequency range of sinusoidal rotation extending from 0·004 to 0·9 Hz.
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Abstract: 1. The neural response of semicircular canal-dependent units in the vestibular nuclei of cats has been examined over a frequency range of sinusoidal rotation extending from 0.004 to 0.9 Hz.2. Frequency-response analysis indicates that, over the range examined, the information contained in the neural signal received by the brain stem was similar to that expected from the mechanical end-organ.3. Over the experimental frequency range, the relation between neural response and mechanical stimulus was found to be dominated by a single time constant of about 4 sec, such that two response regions can be defined above and below a stimulus frequency of (1/4) rad/sec ( approximately approximately Hz).4. Above this frequency the information content of the neural signal tends towards that of angular velocity and below that frequency it tends towards that of angular acceleration.5. It is inferred (a) that the so-called ;long' time constant of the cat's horizontal canal is about 4 sec and (b) that during most normal head movements containing frequencies below about 1 Hz the informational mode of neural signals generated in the canal and received in the brain stem probably tends towards that of head angular velocity.6. This seems appropriate for the generation of vestibulo-ocular reflex compensation for head movement and for reflex damping (negative velocity feed-back) of unintended head and body movements.7. The average neural gain of central unit responses is estimated at 1264 action potentials/sec, per degree of cupular deflexion. This high value reflects the very small angles of cupular deflexion assessed on the basis of physical characteristics of the canal.8. The results permit a rough estimate of the elastic restoring coefficient of the cupula in the horizontal canal as 2.05 x 10(-3) dyne. cm.
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Citations
Anticipation in the rodent head direction system can be explained by an interaction of head movements and vestibular firing properties.
Matthijs A. A. van der Meer,James J. Knierim,D. Yoganarasimha,Emma R. Wood,Mark C. W. van Rossum +4 more
TL;DR: It is concluded that HD afferent dynamics and the statistics of rat head movements are important in generating HD anticipation and this result contributes to understanding the functional circuitry of the HD system and has methodological implications for studies of HD anticipation.
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Dogfish horizontal canal system: Responses of primary afferent, vestibular and cerebellar neurons to rotational stimulation
TL;DR: The activities of horizontal canal primary afferents, vestibular neurons and neurons in the auricular lobe of the cerebellum were sampled during horizontal head rotation in the dogfish Scyliorhinus canicula to study sinusoidal head rotation and the information content of this afferent signal is faithfully represented by the output of both the Vestibular nuclei and the vestibulocerebellum.
34
Volumetric and Dimensional Measurements of Vestibular Structures in the Squirrel Monkey
TL;DR: Temporal bones of squirrel monkeys which were sectioned either in the routine horizontal plane or in the exact plane of lateral semicircular canal, were used for the volumetric and dimensional measurements.
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The Functional Significance of Semicircular Canal Size
G. Melvill Jones
- 01 Jan 1974
TL;DR: It seems that natural selection in evolution has met with some constraint tending to keep the physical dimensions of these small end-organs within rather closely prescribed size limits, and it is therefore pertinent to enquire into the kind of physiological consequence which might derive from such constraint.
32
A new quantitative model of total endolymph flow in the system of semicircular ducts.
M. Muller,J.H.G. Verhagen +1 more
TL;DR: The present theory of endolymph flow is mainly supported by the outcome of previously performed experiments concerning time constants and rotation of human subjects in different planes.
31
References
Physiology of peripheral neurons innervating semicircular canals of the squirrel monkey. II. Response to sinusoidal stimulation and dynamics of peripheral vestibular system.
César Fernández,Jay M. Goldberg +1 more
TL;DR: The torsion-pendulum model helps clarify the dynamics of the peripheral vestibular apparatus and the procedures employed to estimate the time constants have had their drawbacks.
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