Forchlorfenuron Alters Mammalian Septin Assembly, Organization, and Dynamics

TL;DR: How septins may spatially regulate the interaction of microtubules with MAPs and motor proteins is considered and may constitute a novel regulatory module of micro Tubule organization and function with important implications in the understanding of cancer and neurodegeneration.

TL;DR: A novel target of FCF is revealed and its downstream signaling events are elucidated, suggesting that FCF may hold promise as a potential therapeutic in endometrial cancer.

TL;DR: Septins, conserved GTPases, form large complexes that regulate cellular processes, including cytokinesis, vesicle trafficking, and axon migration, and are implicated in cancer through their role in cell division and protein localization.

TL;DR: This work shows that the SEPT9 gene and Septin 9 (SEPT9) protein are expressed and synthesized during differentiation of human osteoclasts and suggests a role for septins in bone resorption.

TL;DR: It is concluded that bud emergence is not a necessary prerequisite for the completion of DNA replication but is apparently necessary for nuclear division and Cytokinesis and cell separation are not necessary prerequisites for bud emergence, DNA replication, or nuclear division.

TL;DR: It is concluded that septin alone self-assemble into rings, that adaptor proteins recruit septins to actin bundles, and that sePTins help organize these bundles.

TL;DR: The septins are a novel family of proteins that were first recognized in yeast as proteins associated with the neck filaments and appear to be essential for this process in both fungal and animal cells.

TL;DR: The structures reveal a universal bipolar polymer building block, composed of an extended G domain, which forms oligomers and filaments by conserved interactions between adjacent nucleotide-binding sites and/or the amino- and carboxy-terminal extensions.