Forchlorfenuron Alters Mammalian Septin Assembly, Organization, and Dynamics
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TL;DR: It is shown that FCF alters septin assembly in vitro without affecting either actin or tubulin polymerization, and FCF is a promising tool to study mammalian septin organization and functions.
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About: This article is published in Journal of Biological Chemistry. The article was published on 24 Oct 2008. and is currently open access. The article focuses on the topics: Septin.
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Citations
Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT).
Thilo Nölke,Carsten Schwan,Friederike Lehmann,Kristine Østevold,Olivier Pertz,Klaus Aktories +5 more
TL;DR: It is shown that septins (SEPT) are essential for CDT-induced protrusion formation, and the data suggest that CDT usurps conserved regulatory principles involved in microtubule–membrane interaction, depending on sePTins, Cdc42, Borgs, and restructuring of the actin cytoskeleton.
Masters of asymmetry - lessons and perspectives from 50 years of septins.
TL;DR: In this paper, the authors highlight how septins have conserved and adapted their roles as effectors of membrane and cytoplasmic asymmetry across fungi and animals.
Ciliary diffusion barrier: the gatekeeper for the primary cilium compartment.
Qicong Hu,W. James Nelson +1 more
TL;DR: Evidence for a membrane diffusion barrier at the base of the primary cilium is reviewed, and the recent finding of a septin cytoskeleton diffusion barrier is highlighted.
Dynamic Structure of Yeast Septin by Fast Fluctuation-Enhanced Structured Illumination Microscopy.
Longfang Yao,Li Zhang,Liwen Chen,Xingyu Gong,Jiahui Zhong,Baoju Wang,Yiyan Fei,Lan Mi,Jiong Ma +8 more
- 29 Oct 2021
TL;DR: In this article, fast fluctuation-enhanced structured illumination microscopy (fFE-SIM) was used to detect the structure of the septin protein at the cell division site of Saccharomyces cerevisiae.
Septin roles in tumorigenesis.
TL;DR: This review summarizes the current knowledge on the role of septins in tumorigenesis, emphasizing their significance and supporting their use as potential biomarkers in various cancer types.
References
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Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis
TL;DR: It is concluded that bud emergence is not a necessary prerequisite for the completion of DNA replication but is apparently necessary for nuclear division and Cytokinesis and cell separation are not necessary prerequisites for bud emergence, DNA replication, or nuclear division.
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Self- and Actin-Templated Assembly of Mammalian Septins
Makoto Kinoshita,Christine M. Field,Margaret Coughlin,Aaron F. Straight,Timothy J. Mitchison +4 more
TL;DR: It is concluded that septin alone self-assemble into rings, that adaptor proteins recruit septins to actin bundles, and that sePTins help organize these bundles.
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The septins: Roles in cytokinesis and other processes
Mark S. Longtine,Douglas J. Demarini,Maria L. Valencik,Omayma S Al-Awar,Hanna Fares,Claudio De Virgilio,John R. Pringle +6 more
TL;DR: The septins are a novel family of proteins that were first recognized in yeast as proteins associated with the neck filaments and appear to be essential for this process in both fungal and animal cells.
543
Structural insight into filament formation by mammalian septins
Minhajuddin Sirajuddin,Marian Farkasovsky,Florian Hauer,Dorothee Kühlmann,Ian G. Macara,Michael Weyand,Holger Stark,Alfred Wittinghofer +7 more
TL;DR: The structures reveal a universal bipolar polymer building block, composed of an extended G domain, which forms oligomers and filaments by conserved interactions between adjacent nucleotide-binding sites and/or the amino- and carboxy-terminal extensions.
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