Journal Article10.1016/S0022-1139(01)00375-X
Fluorine substituent effects (on bioactivity)
1.3K
TL;DR: The influence of fluorination on acidity, hydrogen-bonding, and lipophilicity that affect compound absorption and distribution is discussed in this paper, and the current perspectives on fluorine steric interactions and the controversial role of hydrogen bonding involving the CF bond are discussed.
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About: This article is published in Journal of Fluorine Chemistry. The article was published on 01 Jun 2001.
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Citations
Mild Synthesis of β‐Amino‐α,α‐difluoro Ketones from Acylsilanes and Trifluoromethyltrimethylsilane in a One‐Pot Imino Aldol Reaction
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Selective synthesis of cis- and trans-2-(methyl/phenyl)-3-(trifluoromethyl)aziridines and their regio- and stereospecific ring opening.
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Multiple Approaches to the In Situ Generation of Anhydrous Tetraalkylammonium Fluoride Salts for SNAr Fluorination Reactions
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Electrochemical carboxylation of fluorocontaining imines with preparation of fluorinated N-phenylphenylglycines
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References
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TL;DR: In this paper, it was concluded that the gauche-butane interaction has been incorrectly interpreted as to origin, and that the relationship between methyl groups is not the cause of the relative instability of gauche conformations.
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Organic Fluorine Hardly Ever Accepts Hydrogen Bonds
Jack D. Dunitz,Robin Taylor +1 more
TL;DR: This article showed that covalently bound fluorine hardly ever acts as a hydrogen-bond acceptor, which is in accord with results of other physicochemical studies and with the physical properties of fluorinated organic compounds.
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Activation of Carbon-Fluorine Bonds by Metal Complexes
TL;DR: A. Reductive Defluorination Using Organometallic Reagents V I. Activation of C-F Bonds via Electron-Deficient Transition-Metal Reagents A. as discussed by the authors.
739
C−H···F Interactions in the Crystal Structures of Some Fluorobenzenes
Venkat R. Thalladi,Hans-Christoph Weiss,Dieter Bläser,Roland Boese,Ashwini Nangia,Gautam R. Desiraju +5 more
TL;DR: The existence and nature of C−H···F−C interactions in crystalline fluorobenzenes 1−3 and 7−10 are discussed in this paper, where the authors compare the C−F−O/C−H−N interactions in these four crystal structures.
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