Journal Article10.1016/S0022-1139(01)00375-X
Fluorine substituent effects (on bioactivity)
1.3K
TL;DR: The influence of fluorination on acidity, hydrogen-bonding, and lipophilicity that affect compound absorption and distribution is discussed in this paper, and the current perspectives on fluorine steric interactions and the controversial role of hydrogen bonding involving the CF bond are discussed.
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About: This article is published in Journal of Fluorine Chemistry. The article was published on 01 Jun 2001.
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Citations
Synthesis and bioactivity evaluation of novel nuciferine derivatives with antihyperuricemia and nephroprotective effects.
Yu-kai Zhang,Jia-shu Chen,Min-min Wang,Chuanhu Wang,Mu-Xuan Wang,Zhen Wang,Qingshan Yang,Bin Sun,Jin-yue Sun,Yu-fa Liu,Chao Liu +10 more
TL;DR: In this article , 30 nuciferine derivatives were designed and synthesized, and the effects of all derivatives on the regulation of URAT1 were studied in a uric acid-induced HK-2 cell model with benzbromarone as a positive control.
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Mixing in adsorbed monolayers: perfluorinated alkanes.
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TL;DR: The mixing behavior of binary combinations of perfluoroalkanes in the bulk and in solid monolayers adsorbed at the graphite/liquid interface, determined by calorimetry and powder diffraction, is reported in this paper.
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C−H···F Interactions in the Crystal Structures of Some Fluorobenzenes
Venkat R. Thalladi,Hans-Christoph Weiss,Dieter Bläser,Roland Boese,Ashwini Nangia,Gautam R. Desiraju +5 more
TL;DR: The existence and nature of C−H···F−C interactions in crystalline fluorobenzenes 1−3 and 7−10 are discussed in this paper, where the authors compare the C−F−O/C−H−N interactions in these four crystal structures.
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