Journal Article10.1016/S0022-1139(01)00375-X
Fluorine substituent effects (on bioactivity)
1.3K
TL;DR: The influence of fluorination on acidity, hydrogen-bonding, and lipophilicity that affect compound absorption and distribution is discussed in this paper, and the current perspectives on fluorine steric interactions and the controversial role of hydrogen bonding involving the CF bond are discussed.
read more
About: This article is published in Journal of Fluorine Chemistry. The article was published on 01 Jun 2001.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Differences in electroactive terpolymers based on VDF, TrFE and 2,3,3,3-tetrafluoropropene prepared by batch solution and semi-continuous aqueous suspension polymerizations
Thibaut Soulestin,Thibaut Soulestin,Vincent Ladmiral,Thierry Lannuzel,Fabrice Domingues Dos Santos,Bruno Ameduri +5 more
TL;DR: In this article, a semi-continuous aqueous suspension polymerization process was used for the synthesis of terpolymers with a more homogeneous composition, and the thermal and ferroelectric properties of the homogeneous and heterogeneous ter polymers were characterized and compared.
17
Total synthesis of trifluoromethylated analogs of macrosphelide A
TL;DR: In this article, trifluoromethylated analogs of macrosphelide A 1 and 2 were designed and synthesized via a series of high stereoselective transformations.
17
Metal-free nucleophilic trifluoromethylselenolation via an iodide-mediated umpolung reactivity of trifluoromethylselenotoluenesulfonate.
TL;DR: A practical method to generate CF3Se− (and RFSe−) anions from shelf-stable reagents under iodide activation is reported, and metal-free nucleophilic trifluoromethylselenolations have been performed with this in situ-generated anion.
17
Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone.
Krzysztof Słomiak,Andrzej Łazarenkow,Lilianna Chęcińska,Joachim Kusz,Justyn Ochocki,Jolanta Nawrot-Modranka +5 more
TL;DR: This preliminary study reports the synthesis, structural assessment, initial microbiological screening and biological testing of the synthesized compounds on cell lines using the XTT-assay, demonstrating antiproliferative and stimulation of proliferation against two cell lines.
Michael addition of N -sulfinyl metalloenamines to β-trifluoromethyl-α,β-unsaturated ester: an efficient access to chiral 4-trifluoromethyl-2-piperidones
TL;DR: In this paper, the conversion of N-sulfinyl metalloenamines to β-trifluoromethyl-α,β-unsaturated ester was investigated.
17
References
Conformational analysis—CI
TL;DR: In this paper, it was concluded that the gauche-butane interaction has been incorrectly interpreted as to origin, and that the relationship between methyl groups is not the cause of the relative instability of gauche conformations.
1K
Organic Fluorine Hardly Ever Accepts Hydrogen Bonds
Jack D. Dunitz,Robin Taylor +1 more
TL;DR: This article showed that covalently bound fluorine hardly ever acts as a hydrogen-bond acceptor, which is in accord with results of other physicochemical studies and with the physical properties of fluorinated organic compounds.
889
Activation of Carbon-Fluorine Bonds by Metal Complexes
TL;DR: A. Reductive Defluorination Using Organometallic Reagents V I. Activation of C-F Bonds via Electron-Deficient Transition-Metal Reagents A. as discussed by the authors.
739
C−H···F Interactions in the Crystal Structures of Some Fluorobenzenes
Venkat R. Thalladi,Hans-Christoph Weiss,Dieter Bläser,Roland Boese,Ashwini Nangia,Gautam R. Desiraju +5 more
TL;DR: The existence and nature of C−H···F−C interactions in crystalline fluorobenzenes 1−3 and 7−10 are discussed in this paper, where the authors compare the C−F−O/C−H−N interactions in these four crystal structures.
704