Fluorine substituent effects (on bioactivity)

TL;DR: Despite vast improvements in recent years, a fast and comprehensive method capable of separating all major PFA and PFA-precursor isomers, while removing interferences is still required before these methods becomes routine in most labs.

TL;DR: A modular set of phosphite-oxazoline (P,N) ligands has been applied to the title reaction, and Computational prediction of enantioselectivities gave very good accuracy.

TL;DR: In this article, the background of the enantioselective fluorination reaction and some successful applications of the methods to the design and synthesis of biologically active products are presented, and two novel approaches using cinchona alkaloid/Selectfluor® combinations and chiral ligands/metal complexes have been pursued.

TL;DR: In this paper, it was concluded that the gauche-butane interaction has been incorrectly interpreted as to origin, and that the relationship between methyl groups is not the cause of the relative instability of gauche conformations.

TL;DR: This article showed that covalently bound fluorine hardly ever acts as a hydrogen-bond acceptor, which is in accord with results of other physicochemical studies and with the physical properties of fluorinated organic compounds.

TL;DR: A. Reductive Defluorination Using Organometallic Reagents V I. Activation of C-F Bonds via Electron-Deficient Transition-Metal Reagents A. as discussed by the authors.

TL;DR: The existence and nature of C−H···F−C interactions in crystalline fluorobenzenes 1−3 and 7−10 are discussed in this paper, where the authors compare the C−F−O/C−H−N interactions in these four crystal structures.