Journal Article10.1016/S0022-1139(01)00375-X
Fluorine substituent effects (on bioactivity)
1.3K
TL;DR: The influence of fluorination on acidity, hydrogen-bonding, and lipophilicity that affect compound absorption and distribution is discussed in this paper, and the current perspectives on fluorine steric interactions and the controversial role of hydrogen bonding involving the CF bond are discussed.
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About: This article is published in Journal of Fluorine Chemistry. The article was published on 01 Jun 2001.
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Citations
Ni-catalyzed asymmetric decarboxylative Mannich reaction for the synthesis of β-trifluoromethyl-β-amino ketones
TL;DR: In this paper, a Ni-catalyzed asymmetric decarboxylative Mannich reaction between (Ss)-N-t-butylsulfinyl-3, 3,3-trifluoro-acetaldimine and β-keto-acids was developed.
21
15-Fluoro prostaglandin FP agonists: a new class of topical ocular hypotensives.
Peter G. Klimko,Mark R. Hellberg,Marsha A. McLaughlin,Najam A. Sharif,Bryon S. Severns,Gary W. Williams,Karen S. Haggard,John B. Liao +7 more
TL;DR: Evaluation of selected ester prodrugs of these 15-fluoro prostaglandins in vivo highlighted their generally low propensity to elicit hyperemia or ocular irritation in rabbits and efficacious intraocular pressure-lowering property in monkeys.
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Adaptable P–X Biaryl Phosphite/Phosphoroamidite‐Containing Ligands for Asymmetric Hydrogenation and C–X Bond‐Forming Reactions: Ligand Libraries with Exceptionally Wide Substrate Scope
Oscar Pàmies,Montserrat Diéguez +1 more
TL;DR: In this personal review, the efforts in the design of ligand libraries for the discovery of suitable metal catalysts for asymmetric hydrogenation and C-X bond-forming reactions are presented.
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Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries.
TL;DR: The strategy relies on the use of an enantiopure aryl α,α-difluoromethyl sulfoxide employed as chiral and removable auxiliary for the stereoselective difluorbinding of carbonyl derivatives.
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Diastereospecific fluorination of substituted azepanes
Alpesh Ramanlal Patel,Fei Liu +1 more
TL;DR: The first fluorination examples of substituted azepanes were prepared by deoxyfluorination diastereospecifically in excellent yields and the absolute configuration at the fluorination site was unambiguously assigned by 2D NMR spectroscopy.
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References
Conformational analysis—CI
TL;DR: In this paper, it was concluded that the gauche-butane interaction has been incorrectly interpreted as to origin, and that the relationship between methyl groups is not the cause of the relative instability of gauche conformations.
1K
Organic Fluorine Hardly Ever Accepts Hydrogen Bonds
Jack D. Dunitz,Robin Taylor +1 more
TL;DR: This article showed that covalently bound fluorine hardly ever acts as a hydrogen-bond acceptor, which is in accord with results of other physicochemical studies and with the physical properties of fluorinated organic compounds.
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Activation of Carbon-Fluorine Bonds by Metal Complexes
TL;DR: A. Reductive Defluorination Using Organometallic Reagents V I. Activation of C-F Bonds via Electron-Deficient Transition-Metal Reagents A. as discussed by the authors.
739
C−H···F Interactions in the Crystal Structures of Some Fluorobenzenes
Venkat R. Thalladi,Hans-Christoph Weiss,Dieter Bläser,Roland Boese,Ashwini Nangia,Gautam R. Desiraju +5 more
TL;DR: The existence and nature of C−H···F−C interactions in crystalline fluorobenzenes 1−3 and 7−10 are discussed in this paper, where the authors compare the C−F−O/C−H−N interactions in these four crystal structures.
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