Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells
TL;DR: In this article , the authors present evidence that flavonoids can block metastasis and induce cell death in cancer cells, and suggest that they can serve as potential therapeutic agents in cancer therapy.
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Abstract: Despite the success of cancer therapy, it has encountered a major obstacle due to the complicated nature of cancer, namely resistance. The recurrence and metastasis of cancer occur when anti-cancer therapeutic agents fail to eradicate all cancer cells. Cancer therapy aims to find the best agent that targets all cancer cells, including those sensitive or resistant to treatment. Flavonoids, natural products from our diet, show anti-cancer effects in different studies. They can inhibit metastasis and the recurrence of cancers. This review discusses metastasis, autophagy, anoikis in cancer cells, and their dynamic relationship. We present evidence that flavonoids can block metastasis and induce cell death in cancer cells. Our research suggests that flavonoids can serve as potential therapeutic agents in cancer therapy.
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Citations
Anticancer Potential of Flavonoids: An Overview with an Emphasis on Tangeretin
Francisco Canindé Ferreira de Luna,Wallax Augusto Silva Ferreira,Samir Mansour Moraes Casseb,Edivaldo Herculano Corrêa de Oliveira +3 more
TL;DR: The antitumor properties of tangeretin, a flavonoid found in citrus fruits that has shown activity against some hallmarks of cancer in several types of cancerous cell lines, are emphasized.
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Unveiling the Power of Flavonoids: A Dynamic Exploration of Their Impact on Cancer through Matrix Metalloproteinases Regulation
Peramaiyan Rajendran
TL;DR: Unveiling the power of flavonoids in regulating matrix metalloproteinases to combat cancer metastasis.
Natural Compounds Used in Targeting Cellular Organelles for Drug Delivery
Sheeja S. Rajan,J. P. Jose Merlin,Rahul Chandran,Heidi Abrahamse +3 more
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A Review on Folklore Uses, Phytoconstituents and Pharmacological Activities of the Genus Berberis
Zulfa Nooreen,Awani K Rai,Poonam Jaisal,Fariha Summayya,Ankita Wal,N. A. Siddique +5 more
TL;DR: Traditional and folkloric uses of the Genus Berberis, an evergreen shrub of about 500 plant species found in subtropical and temperate regions, possess numerous activities like anticancer, antimicrobial, antioxidant, anti-inflammatory, antidiabetic, antiulcer, antiviral and, wound healing and many more.
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Exploring the Anticancer Properties of Sakuranin Flavanone in Human Oropharyngeal Squamous Carcinoma Cells by Studying Its Effects on Caspase-driven Apoptosis, Mitochondrial Membrane Potential (MMP) Loss, Cell Migratory and Invasiveness and m-TOR/PI3K/AKT Signalling Pathway.
Fanyong Kong,Jie Zhai +1 more
TL;DR: Sakuranin flavanone exhibits potent anticancer effects against human oropharyngeal squamous carcinoma cells by inducing apoptosis, inhibiting cell migration and invasion, and targeting the m-TOR/PI3K/AKT signalling pathway.
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