Open Access
Flaviviridae :T he Viruses and Their Replication
Brett D. Lindenbach Heinz-J,Charles M. Rice +1 more
- 01 Jan 2007
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TL;DR: The present research attacked the Flavivirus infection through two mechanisms: Membrane Reorganization and the Compartmentalization and Assembly and Release of Particles from Flaviv virus-infected Cells and Host Resistance to Flaviviral Infection.
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Abstract: FLAVIVIRUSES 1103 Background and Classification 1103 Structure and Physical Properties of the Virion 1104 Binding and Entry 1105 Genome Structure 1106 Translation and Proteolytic Processing 1107 Features of the Structural Proteins 1108 Features of the Nonstructural Proteins 1109 RNA Replication 1112 Membrane Reorganization and the Compartmentalization of Flavivirus Replication 1112 Assembly and Release of Particles from Flavivirus-infected Cells 1112 Host Resistance to Flavivirus Infection 1113
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The 3.8 Å resolution cryo-EM structure of Zika virus
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Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response
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miR-122 – A key factor and therapeutic target in liver disease
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References
Dissociation of NS5 from cell fractions containing West Nile virus-specific polymerase activity.
J B Grun,Margo A. Brinton +1 more
TL;DR: West Nile virus replication complexes were partially purified from cytoplasmic extracts of virus-infected cells by centrifugation through a 20% glycerol cushion without significant loss of in vitro West Nile virus polymerase activity.
70
Determination of the disulfide bond arrangement of dengue virus NS1 protein.
TL;DR: The 12 half-cystines of NS1 proteins are absolutely conserved among flaviviruses, suggesting their importance to the structure and function of these proteins, and provides the basis for further refinement of flavivirus NS1 protein structural models.
70
Insertion of a Sequence Encoding Light Chain 3 of Microtubule-Associated Proteins 1A and 1B in a Pestivirus Genome: Connection with Virus Cytopathogenicity and Induction of Lethal Disease in Cattle
TL;DR: Transient-expression studies revealed that the LC3* sequence is able to induce an additional cleavage of the viral polyprotein in the genome of JaCP, a novel kind of cellular insertion which is flanked by duplicated pestivirus sequences.
70
Facilitation of Cell Adhesion by Immobilized Dengue Viral Nonstructural Protein 1 (NS1): Arginine-Glycine-Aspartic Acid Structural Mimicry within the Dengue Viral NS1 Antigen
Hsin-Hou Chang,Huey-Fen Shyu,Yo-Ming Wang,Der-Shan Sun,Rong-Hwa Shyu,Shiao-Shek Tang,Yao-Shine Huang +6 more
TL;DR: The present study showed that dengue NS1 immobilized on coverslips resulted in more cell adhesion than did the control proteins, and data indicate that RGD structural mimicry exists within the NS1 antigen.
70
Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation.
Mario U. Mondelli,Antonella Cerino,Antonella Lisa,Sabrina Brambilla,Laura Segagni,A. Cividini,Morena Bissolati,Gabriele Missale,Giorgio Bellati,Annalisa Meola,Bruno Bruniercole,Alfredo Nicosia,Giovanni Galfre,Enrico Silini +13 more
TL;DR: Serological responses to synthetic oligopeptides derived from HVR1 sequences of patients with acute and chronic HCV infection obtained at baseline and after a defined follow‐up period provided stronger evidence in support of the contention that HCV variant selection is driven by the host's immune pressure.
69
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