Open Access
Flaviviridae :T he Viruses and Their Replication
Brett D. Lindenbach Heinz-J,Charles M. Rice +1 more
- 01 Jan 2007
1.9K
TL;DR: The present research attacked the Flavivirus infection through two mechanisms: Membrane Reorganization and the Compartmentalization and Assembly and Release of Particles from Flaviv virus-infected Cells and Host Resistance to Flaviviral Infection.
read more
Abstract: FLAVIVIRUSES 1103 Background and Classification 1103 Structure and Physical Properties of the Virion 1104 Binding and Entry 1105 Genome Structure 1106 Translation and Proteolytic Processing 1107 Features of the Structural Proteins 1108 Features of the Nonstructural Proteins 1109 RNA Replication 1112 Membrane Reorganization and the Compartmentalization of Flavivirus Replication 1112 Assembly and Release of Particles from Flavivirus-infected Cells 1112 Host Resistance to Flavivirus Infection 1113
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns
humAn CARCInogens,peRsonAl hAbIts,Iarc Monographs +2 more
- 01 Jan 2012
TL;DR: PReVIously ClAssIfIed by IARC As “CARCInogenIC to humAns (gRoup 1)” And wAs deVeloped by sIx sepARAte woRkIng gRoups: phARmACeutICAls; bIologICAl Agents; ARsenIC, metAls, fIbRes, And dusts; RAdIAtIon; peRsonAl
1.3K
Tick-borne encephalitis
Lars Lindquist,Olli Vapalahti +1 more
TL;DR: The epidemiological and clinical characteristics of tick-borne encephalitis, and biological and virological aspects that are important for understanding the life-cycle and transmission of the virus are reviewed.
994
The 3.8 Å resolution cryo-EM structure of Zika virus
Devika Sirohi,Zhenguo Chen,Lei Sun,Thomas Klose,Theodore C. Pierson,Michael G. Rossmann,Richard J. Kuhn +6 more
TL;DR: The structure is mainly similar to that of other flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors that suggests that differences in this region may influence virus transmission and disease.
745
Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response
TL;DR: The 2′,5′-oligoadenylate synthetase (OAS)/RNase L system is an innate immunity pathway that responds to a pathogen-associated molecular pattern to induce degradation of viral and cellular RNAs and thereby block viral infections.
670
miR-122 – A key factor and therapeutic target in liver disease
Simonetta Bandiera,Simonetta Bandiera,Sébastien Pfeffer,Sébastien Pfeffer,Thomas F. Baumert,Thomas F. Baumert,Mirjam B. Zeisel,Mirjam B. Zeisel +7 more
TL;DR: This review summarizes the current understanding of the key role of miR-122 in liver physiology and disease and discusses the perspectives of miRNA-based therapeutic approaches for viral hepatitis and liver disease.
580
References
Deglycosylation of the NS1 protein of dengue 2 virus, strain 16681: construction and characterization of mutant viruses.
TL;DR: The results of the studies indicate that glycosylation of the DENV-2 virus NS1protein may influence NS1 protein processing/transport as well as the pathogenicity of the virus.
76
Genetic Analysis of the Pestivirus Nonstructural Coding Region: Defects in the NS5A Unit Can Be Complemented in trans
TL;DR: Initial insights are provided into the organization of the pestivirus replication machinery by introducing a large spectrum of in-frame mutations into the DI9c ORF.
76
Loss of dimerisation of the nonstructural protein NS1 of Kunjin virus delays viral replication and reduces virulence in mice, but still allows secretion of NS1
Roy A. Hall,Alexander A. Khromykh,Jason M. Mackenzie,Jacqueline H. Scherret,Tatiana Khromykh,John S. Mackenzie +5 more
TL;DR: Results indicate that mutation from proline to leucine at residue 250 in KUN NS1 ablates dimer formation, slows virus replication, and reduces virulence in mice.
76
Structural and Biological Identification of Residues on the Surface of NS3 Helicase Required for Optimal Replication of the Hepatitis C Virus
Samuel G. Mackintosh,Jeff Zhiqiang Lu,John B. Jordan,Melody K. Harrison,Bartek Sikora,Suresh D. Sharma,Craig E. Cameron,Kevin D. Raney,Joshua Sakon +8 more
TL;DR: The biological results suggest that the known biochemical properties associated with the helicase activity of NS3h do not reveal all of the likely biological roles of NS2 during HCV replication, which is not reflective of the large reduction in HCV replicative capacity observed in the biological experiment.
76
Sequential events in the morphogenesis of Japanese encephalitis virus
Kathryn R. Leary,Carol D. Blair +1 more
TL;DR: In Japanese encephalitis virus (JEV)-infected Vero cells, the first ultrastructural evidence of viral replication occurred at 15 hr postinfection (PI) with the appearance of spherical smooth membrane structures (SMS), within the cistenae of the endoplasmic reticulum (ER).
76
Related Papers (5)
Brett D. Lindenbach,Brett D. Lindenbach,Brett D. Lindenbach,Matthew J. Evans,Matthew J. Evans,Matthew J. Evans,Andrew J. Syder,Andrew J. Syder,Andrew J. Syder,Benno Wölk,Benno Wölk,Benno Wölk,Timothy L. Tellinghuisen,Timothy L. Tellinghuisen,Timothy L. Tellinghuisen,Christopher C. Liu,Christopher C. Liu,Christopher C. Liu,Toshiaki Maruyama,Toshiaki Maruyama,Toshiaki Maruyama,Richard O. Hynes,Richard O. Hynes,Richard O. Hynes,Dennis R. Burton,Dennis R. Burton,Dennis R. Burton,Jane A. McKeating,Jane A. McKeating,Jane A. McKeating,Charles M. Rice,Charles M. Rice,Charles M. Rice +32 more