Open Access
Flaviviridae :T he Viruses and Their Replication
Brett D. Lindenbach Heinz-J,Charles M. Rice +1 more
- 01 Jan 2007
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TL;DR: The present research attacked the Flavivirus infection through two mechanisms: Membrane Reorganization and the Compartmentalization and Assembly and Release of Particles from Flaviv virus-infected Cells and Host Resistance to Flaviviral Infection.
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Abstract: FLAVIVIRUSES 1103 Background and Classification 1103 Structure and Physical Properties of the Virion 1104 Binding and Entry 1105 Genome Structure 1106 Translation and Proteolytic Processing 1107 Features of the Structural Proteins 1108 Features of the Nonstructural Proteins 1109 RNA Replication 1112 Membrane Reorganization and the Compartmentalization of Flavivirus Replication 1112 Assembly and Release of Particles from Flavivirus-infected Cells 1112 Host Resistance to Flavivirus Infection 1113
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TL;DR: Internal cleavage of the NS3 protein of dengue virus 2 (DEN-2) was demonstrated, and it was demonstrated that cleavage occurred at this site, and that prior cleavage between NS2B/NS3 was not necessary.
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In Vitro Infection of Human Peripheral Blood Mononuclear Cells by GB Virus C/Hepatitis G Virus
Marta Fogeda,Sonia Navas,Julio Martín,Mercedes Casqueiro,Elena Rodríguez,Carlos Arocena,Vicente Carreño +6 more
TL;DR: This study has demonstrated, for the first time, GBV-C replication in human lymphoid cells under experimental in vitro infection conditions.
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TL;DR: The direct evidence that purified HCV polymerase catalyzed de novo RNA synthesis in a primer-independent manner using homopolymers and HCV RNA as templates is provided, suggesting that a replication initiation site in theHCV RNA genome is a uridylate.
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