Open Access
Flaviviridae :T he Viruses and Their Replication
Brett D. Lindenbach Heinz-J,Charles M. Rice +1 more
- 01 Jan 2007
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TL;DR: The present research attacked the Flavivirus infection through two mechanisms: Membrane Reorganization and the Compartmentalization and Assembly and Release of Particles from Flaviv virus-infected Cells and Host Resistance to Flaviviral Infection.
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Abstract: FLAVIVIRUSES 1103 Background and Classification 1103 Structure and Physical Properties of the Virion 1104 Binding and Entry 1105 Genome Structure 1106 Translation and Proteolytic Processing 1107 Features of the Structural Proteins 1108 Features of the Nonstructural Proteins 1109 RNA Replication 1112 Membrane Reorganization and the Compartmentalization of Flavivirus Replication 1112 Assembly and Release of Particles from Flavivirus-infected Cells 1112 Host Resistance to Flavivirus Infection 1113
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The 3.8 Å resolution cryo-EM structure of Zika virus
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Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response
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miR-122 – A key factor and therapeutic target in liver disease
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References
Intracellular assembly and secretion of recombinant subviral particles from tick-borne encephalitis virus.
Ivo C. Lorenz,Jürgen Kartenbeck,Anna Mezzacasa,Steven L. Allison,Franz X. Heinz,Ari Helenius +5 more
TL;DR: The results suggest that incorporation of prM and E into RSPs occurs at the ER membrane without other viral elements being required, followed by rapid transport along the compartments of the secretory pathway and secretion.
123
In vitro model for hepatitis c virion production
TL;DR: In this article, a hepatitis C virus (HCV) nucleic acid sequence that comprises from 5' to 3' on the positive-sense nucleic acids a 5' untranslated region (UTR), a full-length open reading frame (ORF) encoding an HCV polyprotein whose cleavage products formed functional components of HCV virus particles and RNA replication machinery, and a 3' to 5' UTR, said sequence being infectious.
Mutational Analysis of Bovine Viral Diarrhea Virus RNA-Dependent RNA Polymerase
Vicky C. H. Lai,C. Cheng Kao,Eric Ferrari,Justin J. Park,Annette S. Uss,Jacquelyn Wright-Minogue,Zhi Hong,Johnson Y. N. Lau +7 more
TL;DR: Recombinant bovine viral diarrhea virus (BVDV) nonstructural protein 5B (NS5B) produced in insect cells has been shown to possess an RNA-dependent RNA polymerase (RdRp) activity and was found to utilize a circular single-stranded DNA as a template for RNA synthesis, suggesting that synthesis does not require ends in the template.
121
Full-length GB virus C (hepatitis G virus) RNA transcripts are infectious in primary CD4 positive T cells
TL;DR: It is demonstrated that RNA transcripts from GBV-C full-length cDNA are infectious in primary CD4-positive T cells, in contrast toRNA transcripts from an infectious hepatitis C virus clone that did not replicate in the same cell culture system.
121
Identification and Characterization of an RNA-Dependent RNA Polymerase Activity within the Nonstructural Protein 5B Region of Bovine Viral Diarrhea Virus
TL;DR: BVDV NS5B protein was active in an in vitro RNA polymerase assay using homopolymeric RNA or BVDV minigenomic RNA templates and the major product was a covalently linked double-stranded molecule generated by a “copy-back” mechanism from the input template RNA.
121
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