Open Access
Flaviviridae :T he Viruses and Their Replication
Brett D. Lindenbach Heinz-J,Charles M. Rice +1 more
- 01 Jan 2007
1.9K
TL;DR: The present research attacked the Flavivirus infection through two mechanisms: Membrane Reorganization and the Compartmentalization and Assembly and Release of Particles from Flaviv virus-infected Cells and Host Resistance to Flaviviral Infection.
read more
Abstract: FLAVIVIRUSES 1103 Background and Classification 1103 Structure and Physical Properties of the Virion 1104 Binding and Entry 1105 Genome Structure 1106 Translation and Proteolytic Processing 1107 Features of the Structural Proteins 1108 Features of the Nonstructural Proteins 1109 RNA Replication 1112 Membrane Reorganization and the Compartmentalization of Flavivirus Replication 1112 Assembly and Release of Particles from Flavivirus-infected Cells 1112 Host Resistance to Flavivirus Infection 1113
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns
humAn CARCInogens,peRsonAl hAbIts,Iarc Monographs +2 more
- 01 Jan 2012
TL;DR: PReVIously ClAssIfIed by IARC As “CARCInogenIC to humAns (gRoup 1)” And wAs deVeloped by sIx sepARAte woRkIng gRoups: phARmACeutICAls; bIologICAl Agents; ARsenIC, metAls, fIbRes, And dusts; RAdIAtIon; peRsonAl
1.3K
Tick-borne encephalitis
Lars Lindquist,Olli Vapalahti +1 more
TL;DR: The epidemiological and clinical characteristics of tick-borne encephalitis, and biological and virological aspects that are important for understanding the life-cycle and transmission of the virus are reviewed.
994
The 3.8 Å resolution cryo-EM structure of Zika virus
Devika Sirohi,Zhenguo Chen,Lei Sun,Thomas Klose,Theodore C. Pierson,Michael G. Rossmann,Richard J. Kuhn +6 more
TL;DR: The structure is mainly similar to that of other flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors that suggests that differences in this region may influence virus transmission and disease.
745
Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response
TL;DR: The 2′,5′-oligoadenylate synthetase (OAS)/RNase L system is an innate immunity pathway that responds to a pathogen-associated molecular pattern to induce degradation of viral and cellular RNAs and thereby block viral infections.
670
miR-122 – A key factor and therapeutic target in liver disease
Simonetta Bandiera,Simonetta Bandiera,Sébastien Pfeffer,Sébastien Pfeffer,Thomas F. Baumert,Thomas F. Baumert,Mirjam B. Zeisel,Mirjam B. Zeisel +7 more
TL;DR: This review summarizes the current understanding of the key role of miR-122 in liver physiology and disease and discusses the perspectives of miRNA-based therapeutic approaches for viral hepatitis and liver disease.
580
References
RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region.
Tatsuya Yamashita,Shuichi Kaneko,Yukihiro Shirota,Weiping Qin,Takahiro Nomura,Kenichi Kobayashi,Seishi Murakami +6 more
TL;DR: The C-terminal region of NS5B, which is dispensable for the RdRP activity, dramatically affected the subcellular localization ofNS5B retaining it in perinuclear sites in transiently overexpressed mammalian cells and may provide some clues to dissecting the molecular mechanism of the HCV replication and also act as a basis for developing new anti-viral drugs.
276
N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases
TL;DR: It is suggested that flavivirus NS3 and the respective pestivirus protein contain at least two functional domains, the N-proximal protease and the C- Proximal helicase one, which is probably involved in the processing of viral non-structural proteins.
275
The native form and maturation process of hepatitis C virus core protein.
Kohichiroh Yasui,Takaji Wakita,Kyoko Tsukiyama-Kohara,Shin-Ichi Funahashi,Masumi Ichikawa,Tadahiro Kajita,Darius Moradpour,Darius Moradpour,Jack R. Wands,Michinori Kohara +9 more
TL;DR: The maturation and subcellular localization of hepatitis C virus (HCV) core protein were investigated with both a vaccinia virus expression system and CHO cell lines stably transformed with HCV cDNA, suggesting that p21 core protein is a component of native viral particles.
275
Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1
Jean-Christophe Meunier,Ronald E. Engle,Kristina Faulk,Ming Zhao,Birke Bartosch,Harvey J. Alter,Suzanne U. Emerson,François-Loïc Cosset,Robert H. Purcell,Jens Bukh +9 more
TL;DR: It was found that HCVpp infectivity was enhanced by human or chimpanzee sera; apolipoprotein C1 alone or as a component of high-density lipoproteins caused this enhancement.
274
Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway
TL;DR: Insight is provided into the effects of HCV replication on intracellular events and the mechanisms underlying liver pathogenesis as cells expressing HCV replicons have lower levels of phosphorylation of the α subunit of eukaryotic initiation factor 2 and cap-independent internal ribosome entry site-mediated translation directed by the 5′ noncoding region ofHCV and GRP78 is activated.
274
Related Papers (5)
Brett D. Lindenbach,Brett D. Lindenbach,Brett D. Lindenbach,Matthew J. Evans,Matthew J. Evans,Matthew J. Evans,Andrew J. Syder,Andrew J. Syder,Andrew J. Syder,Benno Wölk,Benno Wölk,Benno Wölk,Timothy L. Tellinghuisen,Timothy L. Tellinghuisen,Timothy L. Tellinghuisen,Christopher C. Liu,Christopher C. Liu,Christopher C. Liu,Toshiaki Maruyama,Toshiaki Maruyama,Toshiaki Maruyama,Richard O. Hynes,Richard O. Hynes,Richard O. Hynes,Dennis R. Burton,Dennis R. Burton,Dennis R. Burton,Jane A. McKeating,Jane A. McKeating,Jane A. McKeating,Charles M. Rice,Charles M. Rice,Charles M. Rice +32 more