Journal Article10.1080/14760584.2018.1457443
Flagellin as a vaccine adjuvant.
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TL;DR: Combinations of flagellin-adjuvanted vaccines with other adjuvants that act in a synergistic manner, particularly TLR ligands, represent a promising method for tailoring targeted vaccines to meet specific requirements.
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Abstract: Introduction: Bacterial flagellin, as a pathogen-associated molecular pattern (PAMP), can activate both innate and adaptive immunity. Its unique structural characteristics endow an effective and fl...
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Inflammasomes and adaptive immune responses
TL;DR: In this article, the interplay between inflammasomes and adaptive immunity is discussed, and the authors consider how distinct tissue or cellular contexts may alter the effects of Inflammasome activation on adaptive immunity and how this contributes to beneficial or detrimental outcomes in infectious diseases, cancer and autoimmunity.
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An Overview of Vaccine Adjuvants: Current Evidence and Future Perspectives
TL;DR: Research into adjuvants could play a leading role in the production of increasingly effective vaccines as modern technologies such as nanotechnologies and molecular biology have forcefully entered the production processes of both antigen and adjuvant components.
Bacterial Protein Toll-Like-Receptor Agonists: A Novel Perspective on Vaccine Adjuvants.
TL;DR: Protein adjuvants can be genetically fused to protein antigens which ensure the co-delivery of adjuvant-antigen not only into the same cell but also in the same endocytic cargo, leading to more effective activation of innate and adaptive immune response.
Selection of adjuvants for vaccines targeting specific pathogens
TL;DR: In-depth understanding of the role of adjuvants in activating the innate immune system, combined with systems vaccinology approaches, have led to the development of next-generation, novel adjuvant that can be used in vaccines against challenging pathogens and in specific target populations.
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Studies on the Use of Flagellin as an Immunostimulant and Vaccine Adjuvant in Fish Aquaculture.
TL;DR: Flagellin could be a potent immunostimulant and vaccine adjuvant for fish aquaculture, as deletion of the N-terminal, C terminal or middle domain of YRF led to functional loss.
References
Antigen-Containing Liposomes Engrafted with Flagellin-Related Peptides Are Effective Vaccines That Can Induce Potent Antitumor Immunity and Immunotherapeutic Effect
Abdus Faham,Joseph G. Altin +1 more
TL;DR: Vaccination with Ag-containing liposomes engrafted with 9Flg or 42Flg is a powerful strategy to exploit the innate and adaptive immune systems for the development of potent vaccines and cancer immunotherapies.
Fusion protein of TLR5-ligand and allergen potentiates activation and IL-10 secretion in murine myeloid DC.
Stefan Schülke,Zoe Waibler,Marc Stefan Mende,Gianni Zoccatelli,Stefan Vieths,Masako Toda,Stephan Scheurer +6 more
TL;DR: Investigation of the adjuvant activity of Listeria monocytogenesis-derived TLR5-ligand flagellin A genetically fused to ovalbumin (Ova, major chicken white egg allergen) in a murine in vitro system showed an enhanced immune modulating capacity in comparison to rflAA or the mixture of rflaA and antigen.
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Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni
TL;DR: Intranasal immunization with this peptide expressed in flagellin, without the addition of adjuvants, resulted in a significant humoral response and also led to protection against challenge infection, manifested as a reduction of the worm burden by an average of 42%.
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The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models
TL;DR: The use of lipopeptides in ALM-containing vaccines did not provide any protection upon infection with L. major, and Pam2 exacerbated the disease severity in vaccinated mice post-challenge, indicating that TLR2/6-targeting ligands could be considered as adjuvants for vaccines that require robust Th2 and/or antibody-dependent immunity.
An avian influenza A (H7N9) virus vaccine candidate based on the fusion protein of hemagglutinin globular head and Salmonella typhimurium flagellin
Li Song,Dan Xiong,Xilong Kang,Yun Yang,Jing Wang,Yaxin Guo,Hui Xu,Sujuan Chen,Daxin Peng,Zhiming Pan,Xinan Jiao +10 more
TL;DR: It is concluded that immunization with HA1-2-fliC induces potentHA1- 2-specific responses, offering significant promise for the development of a successful recombinant subunit vaccine for avian influenza A (H7N9).
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