Journal Article10.1080/14760584.2018.1457443
Flagellin as a vaccine adjuvant.
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TL;DR: Combinations of flagellin-adjuvanted vaccines with other adjuvants that act in a synergistic manner, particularly TLR ligands, represent a promising method for tailoring targeted vaccines to meet specific requirements.
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Abstract: Introduction: Bacterial flagellin, as a pathogen-associated molecular pattern (PAMP), can activate both innate and adaptive immunity. Its unique structural characteristics endow an effective and fl...
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Inflammasomes and adaptive immune responses
TL;DR: In this article, the interplay between inflammasomes and adaptive immunity is discussed, and the authors consider how distinct tissue or cellular contexts may alter the effects of Inflammasome activation on adaptive immunity and how this contributes to beneficial or detrimental outcomes in infectious diseases, cancer and autoimmunity.
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An Overview of Vaccine Adjuvants: Current Evidence and Future Perspectives
TL;DR: Research into adjuvants could play a leading role in the production of increasingly effective vaccines as modern technologies such as nanotechnologies and molecular biology have forcefully entered the production processes of both antigen and adjuvant components.
Bacterial Protein Toll-Like-Receptor Agonists: A Novel Perspective on Vaccine Adjuvants.
TL;DR: Protein adjuvants can be genetically fused to protein antigens which ensure the co-delivery of adjuvant-antigen not only into the same cell but also in the same endocytic cargo, leading to more effective activation of innate and adaptive immune response.
Selection of adjuvants for vaccines targeting specific pathogens
TL;DR: In-depth understanding of the role of adjuvants in activating the innate immune system, combined with systems vaccinology approaches, have led to the development of next-generation, novel adjuvant that can be used in vaccines against challenging pathogens and in specific target populations.
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Studies on the Use of Flagellin as an Immunostimulant and Vaccine Adjuvant in Fish Aquaculture.
TL;DR: Flagellin could be a potent immunostimulant and vaccine adjuvant for fish aquaculture, as deletion of the N-terminal, C terminal or middle domain of YRF led to functional loss.
References
Construction and Immunological Evaluation of Dual Cell Surface Display of HIV-1 Gag and Salmonella enterica Serovar Typhimurium FliC in Lactobacillus acidophilus for Vaccine Delivery
Akinobu Kajikawa,Lin Zhang,Julie Long,Shila K. Nordone,Laura L. Stoeker,Alora LaVoy,Sara Bumgardner,Todd R. Klaenhammer,Gregg A. Dean +8 more
TL;DR: Results suggested that the Gag-displaying L. acidophilus elicited specific immune responses and the coexistence of FliC conferred an adjuvant effect on local IgA production.
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Microneedle delivery of an M2e-TLR5 ligand fusion protein to skin confers broadly cross-protective influenza immunity.
Bao-Zhong Wang,Harvinder S. Gill,Cheng He,Changbo Ou,Li Wang,Yingchun Wang,Hao Feng,Han Zhang,Mark R. Prausnitz,Richard W. Compans +9 more
TL;DR: Protection against homo- and heterosubtypic lethal virus challenges is found to be significantly better than that seen with conventional intramuscular injection, and comparable to that observed with intranasal immunization.
69
Effect of pre-existing carrier immunity on the efficacy of synthetic influenza vaccine
Tamar Ben-Yedidia,Ruth Arnon +1 more
TL;DR: It is demonstrated that the protective effect is not impaired by pre-immunization with either the carrier flagellin molecule alone or with the intact salmonella, concluding that Salmonella flageLLin is a suitable carrier for synthetic peptide based vaccines.
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Immune Responses to Epitopes Inserted in Salmonella Flagellin
TL;DR: Plasmid pLS408 includes gene fliC(d) specifying Salmonella flagellin of antigenic type d with an in vitro deletion of a 48 base-pair EcoRV fragment in its central hypervariable antigenically-determinant region IV.
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A Recombinant Flagellin-Poxvirus Fusion Protein Vaccine Elicits Complement-Dependent Protection Against Respiratory Challenge with Vaccinia Virus in Mice
TL;DR: Flagellin-L1R and flagell in-B5R fusion proteins are effective in eliciting protective immunity against vaccinia virus that is dependent, in large part, on complement.
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