FK506 binding protein associated with the calcium release channel (ryanodine receptor).
Thottala Jayaraman,A.M. Brillantes,A.P. Timerman,Sidney Fleischer,Hediye Erdjument-Bromage,P Tempst,Andrew R. Marks +6 more
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TL;DR: FKBP12 and the RyRec are tightly associated in skeletal muscle SR on the basis of co-purification through sequential heparin-agarose, hydroxylapatite, and size exclusion chromatography columns and subcellular localization of both proteins to the terminal cisternae of the SR, and not in the longitudinal tubules of SR.
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About: This article is published in Journal of Biological Chemistry. The article was published on 15 May 1992. and is currently open access. The article focuses on the topics: Terminal cisternae & Ryanodine receptor.
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Citations
Removal of Fkbp12/12.6 From Endothelial Ryanodine Receptors Leads to an Intracellular Calcium Leak and Endothelial Dysfunction
TL;DR: Complete removal of FKBP12 and 12.6 from endothelial RyRs induces an intracellular Ca2+ leak which may contribute to the pathogenesis of endothelial dysfunction and hypertension caused by rapamycin or FK506.
Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release
TL;DR: There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR) membrane in cardiac myocytes and the relationship between channel structure, associated proteins and function of these Ca channels is discussed.
Effects of ivermectin and midecamycin on ryanodine receptors and the Ca2+-ATPase in sarcoplasmic reticulum of rabbit and rat skeletal muscle
Gerard P. Ahern,Pauline R. Junankar,Suzy M. Pace,Suzanne M. Curtis,Jorgen Mould,Angela F. Dulhunty +5 more
TL;DR: The results confirm the hypothesis that compounds with a macrocyclic lactone ring structure can directly activate RyRs, and effects of ivermectin on SR Ca2+ handling may explain some effects of the macrolide drugs on mammals.
The InsP3 receptor and intracellular Ca2+ signaling
TL;DR: The inositol 1,4,5-trisphosphate receptors plays an important role in intracellular Ca2+ signaling in a wide variety of cell types and has been demonstrated by gene targeting in mice and by studies of T-cell receptor signaling, apoptosis, meiotic maturation, and cytokinesis.
Calcium channel antagonism reduces exercise-induced ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia patients with RyR2 mutations.
TL;DR: The influence of the calcium channel blockers, verapamil and magnesium, on exercise‐induced ventricular arrhythmias in patients with RyR2 mutations is examined.
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Jun Liu,Jesse D. Farmer,Willam S. Lane,Jeffrey S. Friedman,Irving L. Weissman,Stuart L. Schreiber +5 more
TL;DR: The results suggest that calcineurin is involved in a common step associated with T cell receptor and IgE receptor signaling pathways and that cyclophilin and FKBP mediate the actions of CsA and Fk506 by forming drug-dependent complexes with and altering the activity of calcineURin-calmodulin.
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