FK506 binding protein associated with the calcium release channel (ryanodine receptor).

TL;DR: In this article, the authors provide compounds of Formula I, (I) and salts, hydrates, solvates, complexes, and prodrugs thereof, as well as methods for synthesizing compounds of formula I.

TL;DR: In this article, the authors reviewed the cellular cyclosporin binding proteins, especially the cyclophilin (CPH) family and the related IX-binding proteins, and is restricted to mammalian proteins.

TL;DR: Evidence is presented that FKBP12.6 associated with RyR may be required for Ca2+ release induced by cADPR in bovine adrenal chromaffin cells, which is essential for ACh-stimulated CA release.

TL;DR: The cloning and characterization of a novel gene, termed FAP1, is reported, which confers resistance to rapamycin by competing with the drug for binding to FKBP12, a member of an evolutionarily conserved family of putative transcription factors that includes human NF‐X1, Drosophila melanogaster shuttle craft and previously undescribed homologues.

TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.

TL;DR: A discontinuous sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) system for the separation of proteins in the range from 1 to 100 kDa is described, and the omission of glycine and urea prevents disturbances which might occur in the course of subsequent amino acid sequencing.

TL;DR: The results suggest that calcineurin is involved in a common step associated with T cell receptor and IgE receptor signaling pathways and that cyclophilin and FKBP mediate the actions of CsA and Fk506 by forming drug-dependent complexes with and altering the activity of calcineURin-calmodulin.