FK506 binding protein associated with the calcium release channel (ryanodine receptor).
Thottala Jayaraman,A.M. Brillantes,A.P. Timerman,Sidney Fleischer,Hediye Erdjument-Bromage,P Tempst,Andrew R. Marks +6 more
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TL;DR: FKBP12 and the RyRec are tightly associated in skeletal muscle SR on the basis of co-purification through sequential heparin-agarose, hydroxylapatite, and size exclusion chromatography columns and subcellular localization of both proteins to the terminal cisternae of the SR, and not in the longitudinal tubules of SR.
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About: This article is published in Journal of Biological Chemistry. The article was published on 15 May 1992. and is currently open access. The article focuses on the topics: Terminal cisternae & Ryanodine receptor.
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Citations
Gating of the skeletal calcium release channel by ATP is inhibited by protein phosphatase 1 but not by Mg2
TL;DR: The new finding is that channel gating by ATP can be controlled by the state of phosphorylation without inhibition by free Mg2+.
46
Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency.
Mark A. Oyama,Steve Reiken,Stephan E. Lehnart,Sridar V. Chittur,Kathryn M. Meurs,Joshua A. Stern,Andrew R. Marks +6 more
TL;DR: Calstabin2 deficiency is a potential mechanism of Ca(2+) leak-induced ventricular arrhythmias and heart disease in Boxer dogs with ARVC and was associated with a significantly increased open probability of single RyR2 channels indicating intracellular Ca( 2+) leak.
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N-terminal Region of FKBP12 Is Essential for Binding to the Skeletal Ryanodine Receptor
TL;DR: The results suggest that the N-terminal regions of FKBP12 (Gln-3 and Arg-18 and Met-49 are essential and unique for binding of FkBP12 to RyR1 in skeletal muscle.
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SH oxidation coordinates subunits of rat brain ryanodine receptor channels activated by calcium and ATP
TL;DR: Noise analysis of single-channel fluctuations of low-Po channels at 10 microM [Ca2+] plus ATP revealed the presence of subconductance states, suggesting a conduction mechanism that involves four independent subch channels on oxidation the subchannels opened and closed in a concerted mode.
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Deletion of amino acids 1641-2437 from the foot region of skeletal muscle ryanodine receptor alters the conduction properties of the Ca release channel
TL;DR: To understand the contribution of the foot structure to the function of the calcium release channel, a RyR deletion mutant, delta(1641-2437)-RyR, was studied, in which a region that is rich in glutamate and aspartate residues was removed.
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Jun Liu,Jesse D. Farmer,Willam S. Lane,Jeffrey S. Friedman,Irving L. Weissman,Stuart L. Schreiber +5 more
TL;DR: The results suggest that calcineurin is involved in a common step associated with T cell receptor and IgE receptor signaling pathways and that cyclophilin and FKBP mediate the actions of CsA and Fk506 by forming drug-dependent complexes with and altering the activity of calcineURin-calmodulin.
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