FK506 binding protein associated with the calcium release channel (ryanodine receptor).
Thottala Jayaraman,A.M. Brillantes,A.P. Timerman,Sidney Fleischer,Hediye Erdjument-Bromage,P Tempst,Andrew R. Marks +6 more
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TL;DR: FKBP12 and the RyRec are tightly associated in skeletal muscle SR on the basis of co-purification through sequential heparin-agarose, hydroxylapatite, and size exclusion chromatography columns and subcellular localization of both proteins to the terminal cisternae of the SR, and not in the longitudinal tubules of SR.
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About: This article is published in Journal of Biological Chemistry. The article was published on 15 May 1992. and is currently open access. The article focuses on the topics: Terminal cisternae & Ryanodine receptor.
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Citations
Calmodulin and immunophilin are required as functional partners of a ryanodine receptor in ascidian oocytes at fertilization.
TL;DR: It is suggested that exocytosis in ascidian eggs is triggered at fertilization by a functional Ca(2+) release unit operating as a complex of several proteins, including a calmodulin and an immunophilin, around the intracellular calcium channel itself.
Physical coupling between ryanodine receptor-calcium release channels.
TL;DR: It is shown that in reconstituted "checkerboard-like" lattices that mimic in situ membrane channel arrays, each oligomer is interlocked physically with four adjacent oligomers via a specific domain-domain interaction.
The ryanodine receptor in cardiac physiology and disease.
TL;DR: Over the past 20 years advances in the field of ryanodine receptor (RyR2)/calcium release channel research have greatly advanced the understanding of cardiac physiology and the pathogenesis of heart failure and arrhythmias.
Rapamycin inhibits vascular smooth muscle cell migration.
Michael Poon,Steven O. Marx,Richard L. Gallo,Juan J. Badimon,Mark B. Taubman,Andrew R. Marks +5 more
TL;DR: In addition to being a potent immunosuppressant and antiproliferative, rapamycin also inhibits SMC migration.
Potential role of calcineurin for brain ischemia and traumatic injury.
TL;DR: It is concluded that calcineurin is a bi-directional enzyme for neuronal cell death, having protective and toxic actions, and the balance of the bi-irectional effects may be important in ischemic and traumatic pathogenesis.
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TL;DR: The results suggest that calcineurin is involved in a common step associated with T cell receptor and IgE receptor signaling pathways and that cyclophilin and FKBP mediate the actions of CsA and Fk506 by forming drug-dependent complexes with and altering the activity of calcineURin-calmodulin.
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