Book Chapter10.1016/B978-0-08-102310-5.00011-4
Five-Membered Ring Systems: With O and N Atoms
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TL;DR: In this paper, a review covers work published in the calendar year 2012 on novel reaction chemistry and new ring synthetic methods for isoxazoles, isoxoxolines, oxazolines and oxadiazoles.
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Abstract: This review covers work published in the calendar year 2012. Novel reaction chemistry and new ring synthetic methods for isoxazoles, isoxazolines, isoxazolidines, oxazoles, oxazolines, oxazolidines, and oxadiazoles are reviewed.
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Oxadiazoles: moiety to synthesis and utilize
TL;DR: In this article, the synthesis of oxadiazoles in four regioisomeric forms and their potential for a wide range of applications is discussed. But, the authors do not discuss the physicochemical properties of these molecules.
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Synthesis of Isoxazolidines by Intramolecular Hydroamination of N-Alkoxyamides in the Presence of a Visible-Light Photoredox Catalyst
TL;DR: In this article, N-Acyl isoxazolidines were obtained in moderate to good yields by intramolecular hydroamination of N-alkoxyamides in the presence of a ruthenium photocatalyst.
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Synthesis of 3-substituted isoxazolidin-4-ols using hydroboration-oxidation reactions of 4,5-unsubstituted 2,3-dihydroisoxazoles.
TL;DR: The significance of the method lies in its variability and applicability to a concise synthesis of various 4-hydroxyisoxazolidines, starting from the readily available C-alkyl/aryl-nitrones.
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Dess-Martin Periodinane (DMP) in Organic Synthesis-A Septennial Update (2015-till date)
Ravi Varala,Vittal Seema,Mohammed Mujahid Alam,Mohammed Amanullah,Narsimhaswamy Dubasi +4 more
TL;DR: Dess-Martin periodinane (DMP) is a widely used oxidizing agent in organic chemistry for various reactions including oxidations, dehydrogenations, hetero and homo-dimerizations, aromatizations, and ring expansions.
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References
Mechanism of the Cobalt Oxazoline Palladacycle (COP)-Catalyzed Asymmetric Synthesis of Allylic Esters
TL;DR: Results are consistent with a novel mechanism in which chelation of the imidate nitrogen to form a cationic palladium(II) intermediate activates the alkene for attack by external carboxylate in the enantiodetermining step.
A direct access to isoxazoles from ynones using trimethylsilyl azide as amino surrogate under metal/catalyst free conditions.
Gadi Ranjith Kumar,Gadi Ranjith Kumar,Yalla Kiran Kumar,Maddi Sridhar Reddy,Maddi Sridhar Reddy +4 more
TL;DR: A general method for isoxazoles from readily available ynones using trimethylsilyl azide as an amino surrogate, likely via an unprecedented hydroazidation of the alkyne and denitrogenative cyclization, is demonstrated.
60
Generation and Regioselective Trapping of a 3,4-Piperidyne for the Synthesis of Functionalized Heterocycles
TL;DR: The generation of the first 3,4-piperidyne is reported and its use as a building block for the synthesis of annulated piperidines and the distortion/interaction model is used to explain the observed regioselectivities.
Synthesis of C-4′Truncated Phosphonated Carbocyclic 2′-Oxa-3′-azanucleosides as Antiviral Agents
Anna Piperno,Salvatore V. Giofrè,Daniela Iannazzo,Roberto Romeo,Giovanni Romeo,Ugo Chiacchio,Antonio Rescifina,Dorota G. Piotrowska +7 more
TL;DR: Preliminary biological assays show that beta-anomers of TPCOANs are able to inhibit the reverse transcriptase of different retroviruses at concentrations in the nanomolar range, with a potency comparable with that of tenofovir.
60
Diaryl and Heteroaryl Sulfides: Synthesis via Sulfenyl Chlorides and Evaluation as Selective anti-Breast-Cancer Agents.
TL;DR: In this article, a mild protocol for the synthesis of diaryl and heteroaryl sulfides is described, in which thiols are converted to sulfenyl chlorides and reacted with arylzinc reagents.
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