Journal Article10.1016/0092-8674(89)90414-5
Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase.
William G. Dunphy,John Newport +1 more
318
TL;DR: Findings suggest that p13 controls the activation of the cdc2 kinase, and that tyrosine dephosphorylation is an important step in this process.
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About: This article is published in Cell. The article was published on 14 Jul 1989. The article focuses on the topics: Tyrosine phosphorylation & Receptor tyrosine kinase.
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Citations
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
Kornelia Polyak,Jun-ya Kato,Mark J. Solomon,Charles J. Sherr,Joan Massagué,James M. Roberts,Andrew Koff +6 more
TL;DR: Cyclin D2-Cdk4 complexes bind competitively to and down-regulate the activity of p27 and may thereby act in a pathway that reverses Cdk2 inhibition and enables G1 progression.
Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2
Jonathon Pines,Tony Hunter +1 more
TL;DR: The nucleotide and predicted amino acid sequence of a human B-type cyclin shows strong homology to the other known cyclins in the central third of the protein, and it is shown that the level of cyclin mRNA is regulated during the cell cycle.
952
Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.
Kun-Liang Guan,Jack E. Dixon +1 more
TL;DR: A recombinant protein-tyrosine-phosphatase expressed in Escherichia coli and purified to a single band by sodium dodecyl sulfate-polyacrylamide gel electrophoresis is suggested to form a covalent thiol phosphate linkage between Cys215 and phosphate.
498
Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.
Wilhelm Krek,Erich A. Nigg +1 more
TL;DR: The results suggest that phosphorylation of Thr 14 and/or Tyr 15 inhibits p34cdc2 kinase activity, in line with the location of these residues within the putative ATP binding site of the kinase.
449
Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.
TL;DR: Findings suggest thatMAP kinase, previously implicated in the early responses of somatic cells to mitogens, is also activated at the onset of meiotic M phase and that MAP kinase can become tyrosine phosphorylated downstream from M-phase-promoting factor activation.
370
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Characterization of the major protein-tyrosine-phosphatases of human placenta.
TL;DR: Peptide mapping following digestion with Achromobacter protease I or Staphylococcus aureus V8 protease supported the view that, whereas protein-tyrosine-phosphatase subtypes 1A and 1B are different, their soluble and particulate counterparts are closely related structurally and are distinct from serine/threonine phosphatases 1 and 2A.
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