Field-Effect Transistor Biosensor for Rapid Detection of Ebola Antigen
Yantao Chen,Yantao Chen,Ren Ren,Haihui Pu,Xiaoru Guo,Jingbo Chang,Guihua Zhou,Shun Mao,Michael A. Kron,Junhong Chen +9 more
TL;DR: A reduced graphene oxide-based field-effect transistor method for real-time detection of the Ebola virus antigen using the attractive semiconductor characteristics of graphene-based material, and instantaneously yields highly sensitive and specific detection of Ebola glycoprotein.
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Abstract: The Ebola virus transmits a highly contagious, frequently fatal human disease for which there is no specific antiviral treatment. Therefore, rapid, accurate, and early diagnosis of Ebola virus disease (EVD) is critical to public health containment efforts, particularly in developing countries where resources are few and EVD is endemic. We have developed a reduced graphene oxide-based field-effect transistor method for real-time detection of the Ebola virus antigen. This method uses the attractive semiconductor characteristics of graphene-based material, and instantaneously yields highly sensitive and specific detection of Ebola glycoprotein. The feasibility of this method for clinical application in point-of-care technology is evaluated using Ebola glycoprotein suspended in diluted PBS buffer, human serum, and plasma. These results demonstrate the successful fabrication of a promising field-effect transistor biosensor for EVD diagnosis.
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Citations
Rapid Detection of Microorganisms Based on FET Devices
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Ultrahigh sensitivity and layer-dependent sensing performance of phosphorene-based gas sensors.
Shumao Cui,Haihui Pu,Spencer A. Wells,Zhenhai Wen,Shun Mao,Jingbo Chang,Mark C. Hersam,Junhong Chen +7 more
TL;DR: The PNS sensor exhibits an ultrahigh sensitivity to NO2 in dry air and the sensitivity is dependent on its thickness, and the dependence of sensitivity on the PNS thickness is dictated by the band gap for thinner sheets and by the effective thickness on gas adsorption for thicker sheets.
Assessment of the Risk of Ebola Virus Transmission from Bodily Fluids and Fomites
Daniel G. Bausch,Daniel G. Bausch,Jonathan S. Towner,Scott F. Dowell,Felix Kaducu,Matthew Lukwiya,Anthony Sanchez,Stuart T. Nichol,Thomas G. Ksiazek,Pierre E. Rollin +9 more
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