Journal Article10.1016/J.IJCARD.2010.04.053
Fibrosis in endstage human heart failure: Severe changes in collagen metabolism and MMP/TIMP profiles
V. Polyakova,Ivo Loeffler,Stefan Hein,Shigeru Miyagawa,Izabela Piotrowska,Sebastian Dammer,Juha Risteli,Jutta Schaper,Sawa Kostin +8 more
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TL;DR: Although different degrees of severity of collagen metabolism, MMP/TIMP imbalance and cytokine expression in diverse forms of HF are present, the end product is collagen deposition, suggesting multiple mechanisms acting alone or in concert in fibrosis development in HF.
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About: This article is published in International Journal of Cardiology. The article was published on 18 Aug 2011. The article focuses on the topics: TIMP1 & Fibrosis.
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Citations
The role of TIMPs in regulation of extracellular matrix proteolysis.
TL;DR: It is suggested that the divergent roles of TIMPs in matrix accumulation and proteolysis, which together can be referred to as ECM turnover, are dependent on the TIMP, specific tissue, and local tissue environment (i.e. health vs. injury/disease).
670
Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines
Nicolas Venteclef,Valeria Guglielmi,Elise Balse,Bénédicte Gaborit,Aurélie Cotillard,Fabrice Atassi,Julien Amour,Pascal Leprince,Anne Dutour,Karine Clément,Stéphane N. Hatem +10 more
TL;DR: This study provides the first evidence that the secretome from EAT promotes myocardial fibrosis through the secretion of adipo-fibrokines such as Activin A.
Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure
Chandan K. Nagaraju,Emma L. Robinson,Mouna Abdesselem,Sander Trenson,Eef Dries,Guillaume Gilbert,Stefan Janssens,Johan Van Cleemput,Filip Rega,Bart Meyns,H. Llewelyn Roderick,Ronald B. Driesen,Karin R. Sipido +12 more
TL;DR: MyoFb in end-stage HF have a variable degree of differentiation and retain the capacity to return to a less activated state, validating the potential for developing antifibrotic therapy targeting MyOFb.
154
Paeoniflorin suppresses TGF-β mediated epithelial-mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway.
Yu Ji,Yannong Dou,Qian-wen Zhao,Ji-zhou Zhang,Yan Yang,Ting Wang,Yufeng Xia,Yue Dai,Zhifeng Wei +8 more
TL;DR: Paeoniflorin suppresses the early stages of TGF-β mediated EMT in alveolar epithelial cells, likely by decreasing the expression of the transcription factors Snail via a Smad-dependent pathway involving the up-regulation of Smad7.
Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology.
Dong Fan,Zamaneh Kassiri +1 more
TL;DR: An overview of TIMP3 gene structure, transcriptional and post-transcriptional regulators (transcription factors and microRNAs), protein structure and partners, its role in cardiovascular pathology and its application as therapy, while also drawing reference from TIMp3 function in other diseases.
References
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TL;DR: Atrial fibrosis in AF is characterized by severe alterations in collagen I and III synthesis/degradation associated with disturbed MMP/TIMP systems and increased levels of RECK.
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