Journal Article10.4103/0976-433X.149592
Fibroblast growth factors and their role in disease and therapy
Dipten Dey,Nandhini G,K Rajkumar +2 more
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TL;DR: The basic mechanism for FGF action, and their receptors, various functions of FGFs in normal development, their role in cancer formation along with oral diseases and treatment are discussed.
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Abstract: Fibroblast growth factors (FGFs) make up a large family of multifunctional polypeptide growth factors of which there are 22 distinct members. The FGF family shows a high affinity for heparin and also interacts with FGF receptors. FGF can be classified into subgroups according to structures, biochemical properties, and expression. Members of FGF family have been identified in a variety of organisms, and they play a significant role in many cellular processes including mitogenesis differentiation, migration, and cell survival. However, it also has the potentiality to induce oral neoplasms, and various FGFs can be used for therapeutic purpose as well. This review discusses the basic mechanism for FGF action, and their receptors, various functions of FGFs in normal development, their role in cancer formation along with oral diseases and treatment.
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Citations
Triethyl orthoformate covalently cross-linked chitosan-(poly vinyl) alcohol based biodegradable scaffolds with heparin-binding ability for promoting neovascularisation
Lubna Shahzadi,Muhammad Yar,Arshad Jamal,Saadat Anwar Siddiqi,Aqif Anwar Chaudhry,Saba Zahid,Muhammad Tariq,Ihtesham Ur Rehman,Sheila MacNeil +8 more
TL;DR: This study continues the development of hydrogels for wound healing purposes by exploring covalently cross-linking chitosan and polyvinyl alcohol Hydrogels using triethyl orthoformate.
Implications of Fibroblast Growth Factors (FGFs) in Cancer: From Prognostic to Therapeutic Applications
TL;DR: Deregulation of FGF/FGFR-related mechanisms in human disease and tumor progression leading to the presentation of emerging therapeutic approaches, resistance to FGFR targeting, and clinical potentials of individual FGF family in several human cancers are described.
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Developing sulfur-doped titanium oxide nanoparticles loaded chitosan/cellulose-based proangiogenic dressings for chronic ulcer and burn wounds healing.
Abdur Raheem Aleem,Abdur Raheem Aleem,Lubna Shahzadi,Muhammad Nasir,Pegah Hajivand,Farah Alvi,Amna Akhtar,Mubashra Zehra,Mubashra Zehra,Azra Mehmood,Muhammad Yar +10 more
TL;DR: A readily available and inexpensive titanium oxide was added as a potential proangiogenic agent based on their group findings and other reports on metal oxide nanoparticles activity to stimulate angiogenesis as mentioned in this paper.
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Brief overview: Protective roles of astrocyte-derived pentraxin-3 in blood-brain barrier integrity
Brooke Bonsack,Mia C Borlongan,Eng H. Lo,Ken Arai +3 more
- 01 Jul 2019
TL;DR: Evidence was found to suggest that astrocytes play a key role in stroke by expressing PTX3, which, in turn, enhances endothelial tightness, increases tight junction proteins, and inhibits vascular endothelial growth factor.
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Aggressive Prolactin-Secreting Pituitary Adenomas and Carcinomas
Dongyun Zhang,Anthony P. Heaney +1 more
- 01 Jan 2019
TL;DR: This chapter provides an overview of current knowledge regarding the various tools used to diagnose aggressive prolactin-secreting tumors and discusses both established and emerging therapeutic options.
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