Journal Article10.1002/NBM.781
Fiber tracking: Principles and strategies - A technical review
Susumu Mori,Peter C.M. van Zijl +1 more
TL;DR: The state of the art of reconstruction of the axonal tracts in the central nervous system (CNS) using diffusion tensor imaging (DTI) is reviewed, including both data acquisition and the elaborate fiber reconstruction algorithms.
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Abstract: The state of the art of reconstruction of the axonal tracts in the central nervous system (CNS) using diffusion tensor imaging (DTI) is reviewed. This relatively new technique has generated much enthusiasm and high expectations because it presently is the only approach available to non-invasively study the three-dimensional architecture of white matter tracts. While there is no doubt that DTI fiber tracking is providing exciting new opportunities to study CNS anatomy, it is very important to understand its limitations. In this review we therefore assess the basic principles and the assumptions that need to be made for each step of the study, including both data acquisition and the elaborate fiber reconstruction algorithms. Special attention is paid to situations where complications may arise, and possible solutions are reviewed. Validation issues and potential future directions and improvements are also discussed.
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Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: Application to white matter fiber tract mapping in the human brain
Sinisa Pajevic,Carlo Pierpaoli +1 more
TL;DR: Directionally encoded color (DEC) maps of the human brain obtained using empirical or heuristic schemes clearly show the main association, projection, and commissural white matter pathways.
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Microstructure of temporo-parietal white matter as a basis for reading ability: evidence from diffusion tensor magnetic resonance imaging.
Torkel Klingberg,Maj Hedehus,Elise Temple,Talya Salz,John D. E. Gabrieli,Michael E. Moseley,Russell A. Poldrack +6 more
TL;DR: White matter diffusion anisotropy in the temporo-parietal region of the left hemisphere was significantly correlated with reading scores within the reading-impaired adults and within the control group, demonstrating specificity of the group difference to the microstructural characteristics measured by diffusion tensor imaging (DTI).
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