FGF-10 is a chemotactic factor for distal epithelial buds during lung development.

TL;DR: In this paper, a review of the early stages of lung branching morphogenesis is presented, which involves the stereotypic, recurrent definition of new branch points, subsequent epithelial budding, and lung tube elongation.

TL;DR: In this article, the contribution of FGF23 and α-klotho signaling in the pathogenesis of acute and chronic lung disease was discussed, and modulation of fGF23 signaling was discussed as future treatment options for pulmonary disease.

TL;DR: In this paper , the authors described the application and challenges of differentiating ESCs or iPSCs into cells of a respiratory lineage, including the factors required at each stage and the markers and phenotypes associated with the different respiratory cell types.

TL;DR: In this article, the authors showed that the SVEP1 extracellular matrix protein is critical for airway patterning and for the process of transitioning from branching to alveolar maturation.

TL;DR: An antagonist of FGF signaling that patterns apical branching of the Drosophila airways is described and sprouty encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as FGF antagonists in vertebrate development.

TL;DR: The results suggest that this FGF pathway specifies the tracheal branching pattern by guidingtracheal cell migration during primary branch formation and then activating later programs of finer branching at the ends of growing primary branches.

TL;DR: Findings provide direct genetic evidence that FGF/FGFR2 signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction.

TL;DR: To block the function ofFGFR2 during branching morphogenesis of the lung without affecting its function in other embryonic tissues, the human surfactant protein C promoter was used to target expression of a dominant negative FGFR2 exclusively to lung bud epithelium in transgenic mice.