Patent
FET-type biosensor with surface modification
Jeo-young Shim,Su-Hyeon Kim,Kyu-Tae Yoo,Sung-Ouk Jung,Joon-Shik Park +4 more
- 20 Jan 2006
19
TL;DR: In this paper, the surface of a gate of an FET sensor with a ligand that can bind to a side of a nucleic acid was used to increase the debye length.
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Abstract: Provided is a field effect transistor (FET) type biosensor including a source electrode, a gate, and a drain electrode. A ligand that can bind to a side of a nucleic acid is added to the surface of the gate. In a conventional FET type biosensor, it is difficult to detect a signal within the debye length because a target nucleic acid is directly fixed to the surface of a gate of the conventional FET. However, in the present invention, this problem can be overcome and the debye length can be increased by treating the surface of a gate of an FET sensor with a ligand that can bind to a side of a nucleic acid. The ligand can be adsorbed onto the surface of the gate. In this case, the nucleic acid is adsorbed parallel to the surface of the gate, not perpendicular to the surface of the gate, thus generating an effective depletion region. In addition, hybridization efficiency can be increased because a hybridized sample can be injected into an FET sensor at high ionic strength.
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Citations
Patent
Graphene-based field-effect transistor biosensors
Junhong Chen,Shun Mao,Ganhua Lu +2 more
- 17 Feb 2012
TL;DR: In this article, a field effect transistor (FET)-based biosensor using thermally reduced graphene-based sheets as a conducting channel decorated with nanoparticle-biomolecule conjugates is described.
39
Patent
Semiconductor FET sensor and method of fabricating the same
Jong Heon Yang,Baek In Bok,Ahn Chang Geun,Chan Woo Park,Kim An Soon,Han Young Yu,Ah Chil Seong,Kim Tae Youb,Myung Sim Jun,Moon Gyu Jang +9 more
- 20 Aug 2008
TL;DR: In this paper, a semiconductor Field Effect Transistor (FET) sensor and a method of fabricating the same is presented. But the method is limited to a single FET sensor.
17
Patent
Biosensor and method of driving the same
Chan Woo Park,Ahn Chang Geun,Ah Chil Seong,Kim Tae Youb,Kim An Soon,Jong Heon Yang,Gun Yong Sung +6 more
- 11 Feb 2010
TL;DR: In this article, the authors proposed a method of driving a bio-device using a transistor and a gate insulating layer to measure a change in threshold voltage according to the change in electric potential between the reference electrode and the gate insulator.
10
Patent
Device and method for detecting biomolecules using adsorptive medium and field effect transistor
Jeo Young Shim,Kyu Tae Yoo,Won-seok Chung,Jung Im Han +3 more
- 22 May 2008
TL;DR: In this article, a semiconductor substrate, a source region and a drain region separately provided at the substrate, and a chamber formed at a substrate including a region between the source regions and the drain region, the chamber configured to contain a sample including the biomolecules, and an electrode which applies a voltage to the sample in the chamber.
9
Patent
Sensor for detection of nucleic acid
Guojun Zhang,Huiyl Jay Chua,Ru Ern Chee,Narayanan Bala Subramanian,Ross Barnard,Uppili Raghavan +5 more
- 20 Nov 2008
TL;DR: In this article, a sensor for detection of target nucleic acid comprising a semiconductor nanostructure and a detection probe was presented. But the detection probe consisted of a polymer with a substantially non-ionic backbone.
6
References
Patent
Field effect transistor for detection of biological reactions
John F. Schenck
- 19 Mar 1976
TL;DR: In this article, a field effect transistor including conventional source and drain electrodes employs, in the gate region, a layer of antibody specific to a particular antigen, which alters the charge of the protein surface layer due to antigen-antibody reaction.
116
Patent
Method of detecting nucleic acid by using DNA microarrays and nucleic acid detection apparatus
Takuya Hitachi High-Technologies Corp. Matsui,Yuji Miyahara,Kumiko Hattori +2 more
- 12 Aug 2002
TL;DR: In this paper, a method involving the step of treating a nucleic acid-containing sample in DNA microarrays provided with a plural number of nuclei acid probe parts having nuclei acids hybridizable with a definite nucleus is described.
83
Patent
Potentiometric dna microarray, process for producing the same and method of analyzing nucleic acid
Yuji Miyahara,Kenji Hitachinaka Yasuda,Kumiko Hattori +2 more
- 19 Dec 2001
TL;DR: In this article, a DNA microarray system whereby measurement can be performed at a low running cost, a low price and yet a high accuracy is presented, where a nucleic acid probe (3) is immobilized on the surface of a gate insulator of an electric field effect transistor and then hybridized with a target gene on the surfaces of the insulator.
80
Potentiometric detection of DNA molecules hybridization using gene field effect transistor and intercalator
TL;DR: The results show that control of hybridization temperature and utilization of intercalator lead to more precise SNP analysis using the gene FET.
64
Patent
Transistor-based apparatus and method for molecular detection and field enhancement
Chan-Long Shieh,Ackley Donald E +1 more
- 07 Aug 1997
TL;DR: In this article, a transistor (10) having a gate (14) located at a binding site is used to sense differential binding events, where electric field enhancement is provided by applying a voltage to the gate and a second sensing transistor can be coupled to the sensing transistor to form a differential pair.
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