Patent
Fet-based sensor for detecting ionic material, ionic material detecting device using the fet-based sensor, and method of detecting ionic material using the fet-based sensor
Kyu-Sang Lee,Kyu-Tae Yoo,Jeo-young Shim,Jin-Tae Kim,Yeon-ja Cho +4 more
- 09 Jan 2007
73
TL;DR: In this article, an FET-based sensor for detecting an ionic material is presented, and a method for detecting ionic materials using the FETbased sensor is described, which includes a sensing chamber including a reference electrode and a plurality of sensing FETs.
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Abstract: Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs.
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Citations
Patent
Methods and apparatus for measuring analytes using large scale fet arrays
Jonathan M. Rothberg,Wolfgang Hinz,Kim L. Johnson,James Bustillo +3 more
- 02 Feb 2011
TL;DR: In this article, a flow expansion chamber is configured to allow fluids to flow from the expansion chamber to the outlet portion and to allow the fluids to interact along the way with material in the array of wells.
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Methods and apparatus for measuring analytes
Jonathan M. Rothberg,Todd Rearick +1 more
- 27 May 2010
TL;DR: In this article, the authors present methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions.
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Methods and apparatus for detecting molecular interactions using FET arrays
Jonathan M. Rothberg,Wolfgang Hinz +1 more
- 09 Sep 2011
TL;DR: In this article, methods and apparatuses relating to large-scale FET arrays for analyte detection and measurement are provided, which can be used to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and biological processes.
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John Nobile,George Thomas Roth,Todd Rearick,Jonathan Schultz,Jonathan M. Rothberg,David Marran +5 more
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TL;DR: In this article, an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes or reaction byproducts is presented.
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Integrated sensor arrays for biological and chemical analysis
Jonathan M. Rothberg,James Bustillo,Mark James Milgrew,Jonathan Schultz,David Marran,Todd Rearick,Kim L. Johnson +6 more
- 22 Oct 2009
TL;DR: In this article, an ion-sensitive field effect transistor has been proposed for large scale pH-based DNA sequencing and other bioscience and biomedical applications, where each of the transistors has a floating gate with a dielectric layer contacting the sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in the fluid.
141
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