Journal Article10.1002/JSFA.1873
Ferulic acid: pharmaceutical functions, preparation and applications in foods
Shiyi Ou,Kin-Chor Kwok +1 more
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TL;DR: Ferulic acid is a phenolic acid of low toxicity; it can be absorbed and easily metabolized in the human body and is used as the raw material for the production of vanillin and preservatives, as a cross-linking agent for the preparation of food gels and edible films, and as an ingredient in sports foods and skin protection agents.
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Abstract: Ferulic acid (4-hydroxy-3-methoxycinnamic acid), an effective component of Chinese medicine herbs such as Angelica sinensis, Cimicifuga heracleifolia and Lignsticum chuangxiong, is a ubiquitous phenolic acid in the plant kingdom. It is mainly conjugated with mono- and oligosaccharides, polyamines, lipids and polysaccharides and seldom occurs in a free state in plants. Ferulic acid is a phenolic acid of low toxicity; it can be absorbed and easily metabolized in the human body. Ferulic acid has been reported to have many physiological functions, including antioxidant, antimicrobial, anti-inflammatory, anti-thrombosis, and anti-cancer activities. It also protects against coronary disease, lowers cholesterol and increases sperm viability. Because of these properties and its low toxicity, ferulic acid is now widely used in the food and cosmetic industries. It is used as the raw material for the production of vanillin and preservatives, as a cross-linking agent for the preparation of food gels and edible films, and as an ingredient in sports foods and skin protection agents. Ferulic acid can be prepared by chemical synthesis and through biological transformation. As polysaccharide ferulate is a natural and abundant source of ferulic acid, preparation of ferulic acid from plant cell wall materials will be a prospective pathway.
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Citations
A lignin-first strategy to recover hydroxycinnamic acids and improve cellulosic ethanol production from corn stover
TL;DR: This paper developed a partial delignification process for corn stover that simultaneously improves accessibility of enzymes to cellulose and recovers hydroxycinnamic acids (HCA) as a value-added product from the lignin.
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Effects of ferulic acid on antioxidant activity in Angelicae Sinensis Radix, Chuanxiong Rhizoma, and their combination.
TL;DR: It was found that FA was one of the main antioxidant constituents in DG, CX and GX, and the roles of FA were DG > CX > GX and the effects of FA varied at different doses in these herbs.
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Novel caffeic acid amide antioxidants: Synthesis, radical scavenging activity and performance under storage and frying conditions
TL;DR: In this paper, 12 dihydro-caffeic acid amides were synthesized in good yields and fully characterised by 1H NMR, 13C NMR and MS.
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Searching for anti-hyperglycemic phytomolecules of Tecoma stans
TL;DR: In this paper, the authors evaluated the effect of leaves methanol extract of Tecoma stans and some of its fractions on starch tolerance in healthy rats, in vitro inhibition of α-amylase, and their effects of sub-chronic administration of glucose, lipid pattern, kidney and liver functions and antioxidant status in streptozotocin (STZ) induced diabetic rats.
Naturally occurring cinnamic acid derivatives prevent amyloid transformation of alpha-synuclein.
Maria Medvedeva,K.V. Barinova,Aleksandra K. Melnikova,Pavel I. Semenyuk,Vasillii Kolmogorov,Petr V. Gorelkin,Alexander Erofeev,Vladimir I. Muronetz +7 more
TL;DR: Nine natural and synthetic cinnamic acid derivatives were studied and it was shown that some of these derivatives prevent ovine prion protein amyloidization, and two studied compounds can be promising candidate drugs for synucleinopathies, including Parkinson's disease.
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