Journal Article10.1002/JSFA.1873
Ferulic acid: pharmaceutical functions, preparation and applications in foods
Shiyi Ou,Kin-Chor Kwok +1 more
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TL;DR: Ferulic acid is a phenolic acid of low toxicity; it can be absorbed and easily metabolized in the human body and is used as the raw material for the production of vanillin and preservatives, as a cross-linking agent for the preparation of food gels and edible films, and as an ingredient in sports foods and skin protection agents.
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Abstract: Ferulic acid (4-hydroxy-3-methoxycinnamic acid), an effective component of Chinese medicine herbs such as Angelica sinensis, Cimicifuga heracleifolia and Lignsticum chuangxiong, is a ubiquitous phenolic acid in the plant kingdom. It is mainly conjugated with mono- and oligosaccharides, polyamines, lipids and polysaccharides and seldom occurs in a free state in plants. Ferulic acid is a phenolic acid of low toxicity; it can be absorbed and easily metabolized in the human body. Ferulic acid has been reported to have many physiological functions, including antioxidant, antimicrobial, anti-inflammatory, anti-thrombosis, and anti-cancer activities. It also protects against coronary disease, lowers cholesterol and increases sperm viability. Because of these properties and its low toxicity, ferulic acid is now widely used in the food and cosmetic industries. It is used as the raw material for the production of vanillin and preservatives, as a cross-linking agent for the preparation of food gels and edible films, and as an ingredient in sports foods and skin protection agents. Ferulic acid can be prepared by chemical synthesis and through biological transformation. As polysaccharide ferulate is a natural and abundant source of ferulic acid, preparation of ferulic acid from plant cell wall materials will be a prospective pathway.
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Citations
Biodegradable Ferulic Acid-Containing Poly(anhydride-ester): Degradation Products with Controlled Release and Sustained Antioxidant Activity
Michelle A. Ouimet,Jeremy Griffin,Ashley L. Carbone-Howell,Wen Hsuan Wu,Nicholas D. Stebbins,Rong Di,Kathryn E. Uhrich +6 more
TL;DR: The polymer degradation products were found to exhibit antioxidant and antibacterial activity comparable to that of free FA, and in vitro cell viability studies demonstrated that the polymer is noncytotoxic toward fibroblasts, rendering the polymer a potential candidate for use as a controlled release system for skin care formulations.
Separation of Ferulic Acid Reagent by Powdered Activated Charcoal
Shi-yi OU,Yan-ling LUO,Ning ZHANG,Cai-huan HUANG +3 more
TL;DR: Powdered activated charcoal effectively separates ferulic acid reagent from solution, exhibiting high adsorption capacity (325-340mg/g) and desorption efficiency with NaOH, while TLC analysis confirms high purity of separated ferulic acid.
Production of Ferulic Acid from Oryzanol by Y.lipolytica Lip2 Enzyme-Catalyzed
Chen ZHANG,Bo YAN,Yong-hong MENG,Yu-rong GUO,Hong DENG,Li-na WEI +5 more
TL;DR: Researchers developed an enzymatic system to produce ferulic acid from oryzanol using Yarrowia lipolytica lipase, achieving a 2.94% yield, and further improved the process by cloning and expressing the lip2 lipase gene in Pichia pastoris.
Synthesis of Methacrylic−Ferulic Acid Copolymer with Antioxidant Properties by Single-Step Free Radical Polymerization
Francesco Puoci,Francesca Iemma,Manuela Curcio,Ortensia Ilaria Parisi,Giuseppe Cirillo,Umile Gianfranco Spizzirri,Nevio Picci +6 more
TL;DR: Good antioxidant activity was demonstrated by obtained materials, showing the efficiency of the polymerization method, and this material could be useful in the pharmaceutical field and in the food industry (food packaging).
Synthesis of water-soluble and gastrointestinal transit-resistant FA-FOS conjugate for targeted delivery to the colon: pharmacokinetics, pharmacodynamics, efficacy
Eldin M. Johnson,Joo-Won Suh +1 more
TL;DR: In this article , the synthesis and characterization of ferulic acid bound to fructo oligosaccharide (FOS) rendering the resultant FA-FOS conjugate water soluble, resistant to gastrointestinal digestion and absorption, along with the capability to deliver a therapeutically meaningful dose of FA to the large intestine.
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