Ferroptosis as a potential target for cancer therapy
Zhen Chen,Weilong Wang,Siti Razila Abdul Razak,Tao Han,Nor Hazwani Ahmad,Xiumin Li +5 more
79
TL;DR: This review summarizes and briefly presents the key pathways of ferroptosis, paying special attention to the regulation of ferraptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers.
read more
Abstract: Abstract Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in human cancer. However, the precise underlying molecular mechanisms and their differential roles in tumorigenesis are unclear. Therefore, in this review, we summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers. Moreover, multiple pharmacological ferroptosis activators are summarized, and the prospect of targeting ferroptosis in cancer therapy is further elucidated.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy
Chloe Springer,Danish Humayun,Rachid Skouta +2 more
TL;DR: The mechanisms of copper-induced cell death, known as cuproptosis, and its potential health and disease implications, including cancer therapy are explored, with the potential to bring significant advancements to modern medicine.
21
Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials
Jinjiang Wang,Jiaxi Li,Jiao Liu,Ho-Sze Lee,Kenneth Nansheng Lin,C. Wang,Tat-San Lau +6 more
TL;DR: This review focuses on elucidating the key mechanisms behind ferroptosis and cuproptosis and summarizes recent clinical applications targeting dysfunctional iron and copper metabolic pathways, and explores their potential as druggable targets in both cancer research and clinical settings.
18
Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors
TL;DR: Ferroptosis, a non-apoptotic cell death, is modulated by antioxidant systems, particularly transcription factors, which regulate lipid peroxidation and iron accumulation, influencing tumorigenesis, neurodegeneration, and other diseases, highlighting a complex interplay between ferroptosis and antioxidant defense pathways.
16
Ferroptosis: a new regulatory mechanism in neuropathic pain
Lu Li,Lingling Guo,Rui Gao,Mengwen Yao,Xinyu Qu,Guangwei Sun,Qi Fu,Cuntao Hu,Guang Han +8 more
TL;DR: This review systematically summarize the recent progress of ferroptosis research in NP to provide a reference for further understanding of its pathogenesis and propose new targets for treatment.
13
Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology
Muhammad Hossein Ashoub,Razieh Razavi,Kamran Heydaryan,Masoud Salavati-Niasari,Mahnaz Amiri +4 more
TL;DR: The article explores the potential of targeting ferroptosis, a new form of regulated cell death, as a new therapeutic strategy for leukemia and discusses the mechanisms of ferroptosis and its role in leukemia and how nanotechnology can enhance the delivery and efficacy of ferroptosis-inducing agents.
11
References
Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway
Jaekyoung Son,Costas A. Lyssiotis,Costas A. Lyssiotis,Haoqiang Ying,Xiaoxu Wang,Sujun Hua,Matteo Ligorio,Rushika M. Perera,Cristina R. Ferrone,Edouard Mullarky,Edouard Mullarky,Ng Shyh-Chang,Ya'an Kang,Jason B. Fleming,Nabeel Bardeesy,John M. Asara,Marcia C. Haigis,Ronald A. DePinho,Lewis C. Cantley,Lewis C. Cantley,Alec C. Kimmelman +20 more
TL;DR: The identification of a non-canonical pathway of glutamine use in human pancreatic ductal adenocarcinoma (PDAC) cells is reported and it is established that the reprogramming of glutamines metabolism is mediated by oncogenic KRAS, the signature genetic alteration in PDAC, through the transcriptional upregulation and repression of key metabolic enzymes in this pathway.
The Hippo pathway and human cancer
TL;DR: The evidence for the Hippo pathway as a cancer signalling network is appraised, and potential mechanisms by which Hippo pathways activity is altered in cancer and emerging therapeutic strategies are discussed.
1.7K
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
Scott J. Dixon,Darpan N Patel,Matthew Welsch,Rachid Skouta,Eric D Lee,Miki Hayano,Ajit G. Thomas,Caroline E Gleason,Nicholas P. Tatonetti,Barbara S. Slusher,Brent R. Stockwell +10 more
TL;DR: Dixon, Patel, et al. as mentioned in this paper found that erastin is a very effective inhibitor of system xc− function and that it is over 1000 times more potent than the previously known best inhibitor, sulfasalazine.
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Vasanthi S. Viswanathan,Matthew J. Ryan,Harshil Dhruv,Shubhroz Gill,Ossia M. Eichhoff,Brinton Seashore-Ludlow,Samuel D. Kaffenberger,John K. Eaton,Kenichi Shimada,Andrew J. Aguirre,Andrew J. Aguirre,Srinivas R. Viswanathan,Srinivas R. Viswanathan,Shrikanta Chattopadhyay,Pablo Tamayo,Pablo Tamayo,Wan Seok Yang,Matthew G. Rees,Sixun Chen,Zarko V. Boskovic,Sarah Javaid,Cherrie Huang,Xiaoyun Wu,Yuen-Yi Tseng,Elisabeth Roider,Dong Gao,James M. Cleary,Brian M. Wolpin,Jill P. Mesirov,Jill P. Mesirov,Daniel A. Haber,Daniel A. Haber,Jeffrey A. Engelman,Jesse S. Boehm,Joanne Kotz,Cindy S. Hon,Yu Chen,William C. Hahn,William C. Hahn,Mitchell P. Levesque,John G. Doench,Michael E. Berens,Alykhan F. Shamji,Paul A. Clemons,Brent R. Stockwell,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber +47 more
TL;DR: Vulnerability to ferroptic cell death induced by inhibition of a lipid peroxidase pathway as a feature of therapy-resistant cancer cells across diverse mesenchymal cell-state contexts is identified.
1.6K
Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis.
Lianjiu Su,Jiahao Zhang,Hernando Gomez,Raghavan Murugan,Xing Hong,Dongxue Xu,Fan Jiang,Zhiyong Peng,Zhiyong Peng +8 more
TL;DR: This review discussed how ROS propagate lipid peroxidation chain reactions and how the products of lipidperoxidation initiate apoptosis and autophagy in current models, and summarized lipid per oxidation in pathological conditions of critical illness.