Book Chapter10.1201/9781420039207.CH12
Fatty Alcohols and Fatty Acids
Ramesh Babu,Mandip Singh,Narayanasamy Kanikkannan +2 more
- 02 Nov 2005
- pp 137-158
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About: The article was published on 02 Nov 2005.
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Citations
Transdermal Drug Delivery Enhancement by Compounds of Natural Origin
TL;DR: A comprehensive summary of the results from scientific research conducted on skin penetration enhancers of natural origin, organized into the following chemical classes: essential oils, terpenes, fatty acids and polysaccharides are given.
Lipid materials for topical and transdermal delivery of nanoemulsions.
TL;DR: This review describes various lipid materials used in the preparation of nanoemulsions for topical and transdermal drug delivery, classified as vegetable oils, fatty acids, fatty alcohols, medium chain glycerides, and fatty acid esters.
53
Penetration enhancing effects of selected natural oils utilized in topical dosage forms
TL;DR: Investigation of possible penetration enhancing properties of selected oils, utilizing flurbiprofen as marker compound in emulgel formulations suggested that oils containing predominantly mono-unsaturated oleic acid, on average increased the flux of the marker to a larger extent than oils containing an almost even mixture of both mono- and poly-uns saturated fatty acids.
51
Emollient molecule effects on the drying stresses in human stratum corneum.
TL;DR: Background Emollient molecules are widely used in skin care formulations to improve skin sensory properties and to alleviate dry skin but little is understood regarding their effects on skin biomechanical properties.
34
Preparation, characterization and permeation studies of a nanovesicular system containing diclofenac for transdermal delivery
TL;DR: The composition of the nanovesicle played an important role in physical properties and drug permeation and also contribute towards stability and non-irritancy in transdermal formulations containing permeation enhancer.
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References
Effects of adhesives and permeation enhancers on the skin permeation of captopril.
TL;DR: A captopril patch may be developed with further optimization after results showed the permeation rate of the drug through the excised skin was dependent on the type of polyacrylate copolymers studied.
35
Enhancement of percutaneous absorption of molsidomine.
Masayuki Yamada,Yoshiaki Uda +1 more
TL;DR: Remarkable percutaneous absorption enhancement was observed in the presence of linoleic acid when a series of unsaturated straight fatty acids with different carbon numbers were substituted for oleic acid, and Lauric acid was the most effective in the series of saturatedstraight fatty acids.
31
Transdermal Oxymorphone Formulation Development and Methods for Evaluating Flux and Lag Times for Two Skin Permeation-Enhancing Vehicles
TL;DR: There were significant differences between human skin and hairless guinea pig skin when comparing in vitro fluxes with the two skin permeation-enhancing formulations and the differences in lag time between formulations could be related to differences in the mechanisms of permeation enhancement.
31
Which bioengineering assay is appropriate for irritant patch testing with sodium lauryl sulfate
TL;DR: When evaluating SLS patch testing by bioengineering methods, TEWL measurement appears to be more suitable for a test procedure that provokes mild skin reactions, whereas LD measurement is more appropriate to evaluate pronounced skin reactions.
31
Transdermal delivery of levosimendan.
Riitta Valjakka-Koskela,Jouni Hirvonen,Jukka Mönkkönen,Juha Kiesvaara,Saila Antila,Lasse Lehtonen,Arto Urtti +6 more
TL;DR: Transdermal delivery of levosimendan can be significantly increased by formulation modification and therapeutic plasma concentrations may be achievable transdermally, based on kinetic calculations.
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