Fatigue in neurological disorders

TL;DR: Although there are few diagnostically specific findings, patterns of association have emerged: where action is impeded (certain forms of conversion disorder and chronic fatigue syndrome) frontal systems of the brain are often implicated and temporo-parietal cortices appear to be dysfunctional.

TL;DR: In this paper, the authors examined the contribution of a mirror visual feedback system to regulate physical fatigue in 12 healthy participants who performed 60 repetitive left handgrips at maximal voluntary contraction every 1 s as a fatigue-inducing physical task session.

TL;DR: In this article, the authors evaluated health-related quality of life, depressive symptoms, fatigue, and physical activity in mild to moderately affected spinocerebellar ataxias (SCAs) patients and examined interrelations between these PROMs and objective disease severity indices.

TL;DR: In a small cohort of patients with paralytic poliomyelitis and post-polio syndrome (PPS) a significant circadian variation of subjective fatigue evaluated by means of a validated scale was observed, showing a progressive worsening of fatigue during afternoon in both PP and PPS.

TL;DR: A fatigue severity scale was internally consistent, correlated well with visual analogue measures, clearly differentiated controls from patients, and could detect clinically predicted changes in fatigue over time and identify features that distinguish fatigue between two chronic medical disorders.

TL;DR: A conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome are developed that cover the clinical and laboratory evaluation of persons with unexplained fatigue; the identification of underlying conditions that may explain the presence of chronic fatigue; revised criteria for defining cases of the Chronic fatigue syndrome; and a strategy for dividing the chronic Fatigue syndrome and other unexplained cases of Chronic fatigue into subgroups.

TL;DR: Experimental NeurologyBy Prof. Paul Glees.

TL;DR: The localization of substance P in brain regions that coordinate stress responses and receive convergent monoaminergic innervation suggested that substance P antagonists might have psychotherapeutic properties was found to be correct.