Journal Article10.1016/S0140-6736(04)15794-2
Fatigue in neurological disorders
Abhijit Chaudhuri,Peter O. Behan +1 more
TL;DR: A state of pre-existing relative hypocortisolaemia might sensitise the hypothalamic-pituitary-adrenal axis to development of persistent central fatigue after stress.
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About: This article is published in The Lancet. The article was published on 20 Mar 2004. The article focuses on the topics: Chronic fatigue & Chronic fatigue syndrome.
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Citations
Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis
Zina-Mary Manjaly,Neil A. Harrison,Neil A. Harrison,Neil A. Harrison,Hugo D. Critchley,Hugo D. Critchley,Hugo D. Critchley,Cao Tri Do,Gábor Stefanics,Nicole Wenderoth,Andreas Lutterotti,Alfred Müller,Klaas E. Stephan +12 more
TL;DR: An overview of contemporary pathophysiological theories of fatigue in MS is provided and it is discussed how the mechanisms they propose may become measurable with emerging technologies and thus lay a foundation for future personalised treatments.
255
Clinical neurophysiology of fatigue.
TL;DR: The reliability of the psychological and clinical neurophysiological assessment techniques available today allows a multidisciplinary approach to fatigue in neurological patients, which may contribute to the elucidation of the pathophysiological mechanisms of chronic fatigue, with the ultimate goal to develop tailored treatments for fatigue in Neurological patients.
254
Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity.
Kei Mizuno,Masaaki Tanaka,Kouzi Yamaguti,Osami Kajimoto,Hirohiko Kuratsune,Yasuyoshi Watanabe +5 more
TL;DR: Sympathetic hyperactivity based on decreased parasympathetic activity is associated with mental fatigue induced by prolonged cognitive load, and the HF was lower and LF/HF ratio was higher as compared to those after the relaxation session.
Fatigue Rating Scales Critique and Recommendations by the Movement Disorders Society Task Force on Rating Scales for Parkinson's Disease
Joseph H. Friedman,Joseph H. Friedman,Guido Alves,Peter Hagell,Johan Marinus,Laura Marsh,Laura Marsh,Pablo Martinez-Martin,Christopher G. Goetz,Werner Poewe,Olivier Rascol,Cristina Sampaio,Glenn T. Stebbins,Anette Schrag +13 more
TL;DR: A task force to assess available clinical rating scales, critique their psychometric properties, summarize their clinical properties, and evaluate the evidence in support of their use in clinical studies inPD concluded that current scales are adequate for fatigue studies in PD but that studies on sensitivity and specificity of the scales are still needed.
245
What do the basal ganglia do? A modeling perspective
TL;DR: The existing modeling literature on BG is reviewed and an integrative picture of the function of these nuclei is hypothesized and has the potential to radically alter treatment and management of BG-related neurological disorders and neuropsychiatric disorders also.
240
References
Protective and Damaging Effects of Stress Mediators
TL;DR: The long-term effect of the physiologic response to stress is reviewed, which I refer to as allostatic load, which is the ability to achieve stability through change.
The Fatigue Severity Scale: Application to Patients With Multiple Sclerosis and Systemic Lupus Erythematosus
TL;DR: A fatigue severity scale was internally consistent, correlated well with visual analogue measures, clearly differentiated controls from patients, and could detect clinically predicted changes in fatigue over time and identify features that distinguish fatigue between two chronic medical disorders.
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The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
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TL;DR: A conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome are developed that cover the clinical and laboratory evaluation of persons with unexplained fatigue; the identification of underlying conditions that may explain the presence of chronic fatigue; revised criteria for defining cases of the Chronic fatigue syndrome; and a strategy for dividing the chronic Fatigue syndrome and other unexplained cases of Chronic fatigue into subgroups.
Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors
Mark S. Kramer,N.R. Cutler,John P. Feighner,Ram K. Shrivastava,John Carman,John J. Sramek,Scott A. Reines,Guanghan Liu,Duane B. Snavely,Edwina Wyatt-Knowles,Jeffrey J. Hale,Sander G. Mills,Malcolm MacCoss,Christopher John Swain,Timothy Harrison,Raymond G. Hill,Franz Hefti,Edward M. Scolnick,Margaret A. Cascieri,Gary G. Chicchi,Sharon Sadowski,Angela Williams,Louise Hewson,David D. Smith,Emma J. Carlson,Richard Hargreaves,Nadia M.J. Rupniak +26 more
TL;DR: The localization of substance P in brain regions that coordinate stress responses and receive convergent monoaminergic innervation suggested that substance P antagonists might have psychotherapeutic properties was found to be correct.
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