Fatigue in neurological disorders

TL;DR: It is argued that CFS pathogenesis lies in the influence of peripheral inflammatory events on the brain and the unique immunophysiology of the central nervous system and the use of anti-TNF biological agents as a reliable and effective treatment approach to CFS.

TL;DR: The methods described here are useful for assessing the association between fatigue sensation and autonomic nerve activity using a brief cognitive test in healthy females.

TL;DR: Grass carp protein or peptide significantly improved the endurance capacity of mice and the superiority of peptide over protein was observed at high-dose supplementation, which was mainly attributed to the significant enhancement of antioxidant enzyme levels (CAT and SOD).

TL;DR: The results suggest that chronic fatigue in patients with MS may be highly invariant over time, irrespective of interventions.

TL;DR: A fatigue severity scale was internally consistent, correlated well with visual analogue measures, clearly differentiated controls from patients, and could detect clinically predicted changes in fatigue over time and identify features that distinguish fatigue between two chronic medical disorders.

TL;DR: A conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome are developed that cover the clinical and laboratory evaluation of persons with unexplained fatigue; the identification of underlying conditions that may explain the presence of chronic fatigue; revised criteria for defining cases of the Chronic fatigue syndrome; and a strategy for dividing the chronic Fatigue syndrome and other unexplained cases of Chronic fatigue into subgroups.

TL;DR: Experimental NeurologyBy Prof. Paul Glees.

TL;DR: The localization of substance P in brain regions that coordinate stress responses and receive convergent monoaminergic innervation suggested that substance P antagonists might have psychotherapeutic properties was found to be correct.