Journal Article10.1016/S0140-6736(04)15794-2
Fatigue in neurological disorders
Abhijit Chaudhuri,Peter O. Behan +1 more
TL;DR: A state of pre-existing relative hypocortisolaemia might sensitise the hypothalamic-pituitary-adrenal axis to development of persistent central fatigue after stress.
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About: This article is published in The Lancet. The article was published on 20 Mar 2004. The article focuses on the topics: Chronic fatigue & Chronic fatigue syndrome.
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Citations
Central nervous system dysfunction in primary biliary cirrhosis and its relationship to symptoms
TL;DR: PBC patients have impaired central activation and abnormal ICI, suggesting CNS abnormalities beyond voluntary control and Transplanted and non-transplanted patients show similar abnormalities raising interesting questions about the mechanisms underpinning these changes and the permanence of neurological dysfunction in PBC.
47
Brain anatomical correlates of fatigue in multiple sclerosis.
TL;DR: The findings of previous structural neuroimaging studies on MS-related fatigue are reviewed and consistent findings regarding brain circuitry associated with fatigue in MS are summarized to contextualize these findings with the neurochemistry of the relevant circuits.
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Prevalence and Predictors of 6-Month Fatigue in Patients With Ischemic Stroke A Population-Based Stroke Incidence Study in Auckland, New Zealand, 2002–2003
Valery L. Feigin,Suzanne Barker-Collo,Varsha Parag,Maree L. Hackett,Ngaire Kerse,Peter Barber,Alice Theadom,Rita Krishnamurthi +7 more
TL;DR: The prevalence of fatigue increased with advancing age, as found in most previous studies, and particular attention needs to be paid to those who are older, incontinent before stroke, and those who report severe symptoms of depression at 6 months after stroke.
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Medial orbitofrontal cortex is associated with fatigue sensation.
Seiki Tajima,Shigeyuki Yamamoto,Masaaki Tanaka,Yosky Kataoka,Masao Iwase,Etsuji Yoshikawa,Hiroyuki Okada,Hirotaka Onoe,Hideo Tsukada,Hirohiko Kuratsune,Yasuomi Ouchi,Yasuyoshi Watanabe +11 more
TL;DR: The brain region exhibiting a positive correlation in activity with subjective sensation of fatigue, measured immediately after each positron emission tomography scan, was located in medial orbitofrontal cortex (Brodmann's area 10/11), which is a brain region associated with mental fatigue sensation.
Qualitative and quantitative assessment of fatigue in multiple sclerosis (MS).
TL;DR: A synoptic multidimensional test system for assessment of fatigue in multiple sclerosis patients objectifying physical and mental fatigue as well as the subjective and objective standpoint in these two fatigue forms is developed.
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