Journal Article10.1016/J.YMGME.2003.08.016
Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
Steven E. Raper,Narendra Chirmule,Frank S. Lee,Nelson A. Wivel,Adam Bagg,Guangping Gao,James M. Wilson,Mark L. Batshaw +7 more
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TL;DR: The death of an 18-year-old male with partial ornithine transcarbamylase (OTC) deficiency who participated in a pilot (safety) study of gene therapy points to the limitations of animal studies in predicting human responses, the steep toxicity curve for replication defective adenovirus vectors, substantial subject-to-subject variation in host responses to systemically administered vectors, and the need for further study of the immune response to these vectors.
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About: This article is published in Molecular Genetics and Metabolism. The article was published on 01 Sep 2003. The article focuses on the topics: Ornithine transcarbamylase deficiency & Ornithine transcarbamylase.
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Viral Vectors for Gene Therapy: Translational and Clinical Outlook
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Innate Immune Response to Adenoviral Vectors Is Mediated by both Toll-Like Receptor-Dependent and -Independent Pathways
TL;DR: It is shown that adenovirus elicited innate immune response through the induction of high levels of type I interferons (IFNs) by both plasmacytoid dendritic cells ( pDCs) and non-pDCs such as conventional DCs and macrophages, and approaches to activate the type I IFN pathway may enhance vaccine potency.
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TL;DR: An overview of the definitions, clinical features, and epidemiology of the acute respiratory distress syndrome is provided and advances in the areas of pathogenesis, resolution, and treatment are discussed.
Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
TL;DR: Approaches for improving recombinant adenoviruses that are based on further crippling the virus to limit expression of nondeleted viral genes are suggested.
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The Pathogenesis of Sepsis
TL;DR: Rather than being caused by any single pathogenic mechanism, it is more likely that sepsis is related to the state of activation of the target cell, the nearby presence of other mediators, and the ability of thetarget cell to release other mediator, so the body can no longer control its own inflammatory response.
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Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses.
TL;DR: This study has used mice deficient in immunological effector functions in combination with adoptive and passive transfer techniques to define antigen-specific cellular and humoral immune responses that underlie immunological barriers to gene therapy of cystic fibrosis.
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Activation of coagulation after administration of tumor necrosis factor to normal subjects.
T. van der Poll,H. R. Büller,H. ten Cate,C. H. Wortel,Kenneth A. Bauer,S. J. H. Van Deventer,C. E. Hack,H. P. Sauerwein,Robert D. Rosenberg,J W ten Cate +9 more
TL;DR: It is concluded that a single injection of tumor necrosis factor elicits a rapid and sustained activation of the common pathway of coagulation, probably induced through the extrinsic route and could play an important part in the earlyactivation of the hemostatic mechanism in septicemia.
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