Journal Article10.1016/J.RADONC.2017.07.028
Fast and robust online adaptive planning in stereotactic MR-guided adaptive radiation therapy (SMART) for pancreatic cancer.
Omar Bohoudi,Anna M.E. Bruynzeel,Suresh Senan,Johan P. Cuijpers,Berend J. Slotman,Frank J. Lagerwaard,Miguel A. Palacios +6 more
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TL;DR: SMART3CM approach for LAPC allows good OAR sparing and adequate target coverage while requiring only limited online (re-)contouring from clinicians.
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About: This article is published in Radiotherapy and Oncology. The article was published on 01 Dec 2017.
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Citations
Stereotactic MR-guided adaptive radiation therapy for peripheral lung tumors.
Tobias Finazzi,Miguel A. Palacios,C.J.A. Haasbeek,Marjan A. Admiraal,Femke O.B. Spoelstra,A. Bruynzeel,Berend J. Slotman,Frank J. Lagerwaard,Suresh Senan +8 more
TL;DR: Delivery of gated breath-hold SABR using MR-guidance resulted in significantly smaller target volumes than would have been the case with an ITV-based approach, suggesting that daily online plan adaptation may not benefit most patients with peripheral lung tumors.
76
Locally Advanced Pancreatic Cancer: A Review of Local Ablative Therapies
Alette H. Ruarus,Laurien G. P. H. Vroomen,Robbert S. Puijk,Hester J. Scheffer,Martijn R. Meijerink +4 more
TL;DR: An overview of available data with regard to morbidity and oncological outcome of novel local therapies for locally advanced pancreatic cancer is provided.
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A New Era of Image Guidance with Magnetic Resonance-guided Radiation Therapy for Abdominal and Thoracic Malignancies.
K Mittauer,Bhudatt R. Paliwal,Patrick M. Hill,John E. Bayouth,M Geurts,Andrew M. Baschnagel,Kristin A. Bradley,Paul M. Harari,Stephen A. Rosenberg,Jeffrey V. Brower,Andrzej P. Wojcieszynski,Craig R. Hullett,R.A.B. Bayliss,Zacariah E. Labby,Michael F. Bassetti +14 more
TL;DR: The abdominal and thoracic sites of the lung, kidney, liver, and gastric targets are described to illustrate the technological advancement of MR-guidance in radiotherapy.
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Dosimetric Benefits and Practical Pitfalls of Daily Online Adaptive MRI-Guided Stereotactic Radiation Therapy for Pancreatic Cancer
Nancy El-Bared,Lorraine Portelance,B. Spieler,Deukwoo Kwon,Kyle R. Padgett,Karen Brown,Eric A. Mellon +6 more
TL;DR: MRI-g OART improves target coverage and OAR sparing for pancreas SBRT, partially results from mitigation of interfraction variability in stomach volume.
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Role of Daily Plan Adaptation in MR-Guided Stereotactic Ablative Radiation Therapy for Adrenal Metastases.
Miguel A. Palacios,Omar Bohoudi,Anna M.E. Bruynzeel,John R. van Sörsen de Koste,Paul Cobussen,Ben J. Slotman,Frank J. Lagerwaard,Suresh Senan +7 more
TL;DR: Significant interfractional changes in OAR positions were observed despite breath-hold stereotactic ablative radiation therapy delivery under MR-guidance, and online reoptimization of treatment plans led to significant improvements in target coverage and OAR sparing.
75
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Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05.
Edward G. Shaw,Charles Scott,Luis Souhami,Robert P. Dinapoli,Robert W. Kline,Jay S. Loeffler,Nancy C. Farnan +6 more
TL;DR: The maximum tolerated doses of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors and brain metastases were defined for this population of patients as 24 Gy, 18 Gy, and 15 Gy for tumors, whereas investigators' reluctance to escalate to 27 Gy, rather than excessive toxicity, determined the maximum tolerated dose.
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Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer.
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TL;DR: It is feasible to deliver stereotactic radiosurgery to patients with locally advanced pancreatic cancer and the recommended dose to achieve local control without significant acute gastrointestinal toxicity is 25 Gy.
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Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer
Devin Schellenberg,Karyn A. Goodman,Florence Lee,Stephanie T. Chang,Timothy Kuo,James M. Ford,George A. Fisher,Andrew Quon,Terry S. Desser,Jeffrey A. Norton,Ralph S. Greco,George P. Yang,Albert C. Koong +12 more
TL;DR: SBRT with gemcitabine resulted in comparable survival to conventional chemoradiotherapy and good local control, however, the rate of duodenal ulcer development was significant.
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Online Magnetic Resonance Image Guided Adaptive Radiation Therapy: First Clinical Applications
Sahaja Acharya,Benjamin W. Fischer-Valuck,Rojano Kashani,Parag J. Parikh,Deshan Yang,Tianyu Zhao,Olga Green,O. Wooten,H. Harold Li,Yanle Hu,Vivian Rodriguez,L. Olsen,Clifford G. Robinson,Jeff M. Michalski,Sasa Mutic,Jeffrey R. Olsen +15 more
TL;DR: Online adaptive MR-IGRT has been successfully implemented with planning and QA workflow suitable for routine clinical application and reported of the initial clinical experience and workflow considerations.
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Stereotactic Body Radiotherapy and Gemcitabine for Locally Advanced Pancreatic Cancer
Anand Mahadevan,Sanjay Jain,Michael Goldstein,Rebecca A. Miksad,Douglas K. Pleskow,Mandeep S. Sawhney,Darren D. Brennan,Mark P. Callery,Charles M. Vollmer +8 more
TL;DR: Hypofractionated SBRT can be delivered quickly and effectively in patients with nonmetastatic, locally advanced, unresectable pancreatic cancer with acceptable side effects and minimal interference with gemcitabine chemotherapy.
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