Journal Article10.1016/J.RADONC.2017.07.028
Fast and robust online adaptive planning in stereotactic MR-guided adaptive radiation therapy (SMART) for pancreatic cancer.
Omar Bohoudi,Anna M.E. Bruynzeel,Suresh Senan,Johan P. Cuijpers,Berend J. Slotman,Frank J. Lagerwaard,Miguel A. Palacios +6 more
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TL;DR: SMART3CM approach for LAPC allows good OAR sparing and adequate target coverage while requiring only limited online (re-)contouring from clinicians.
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About: This article is published in Radiotherapy and Oncology. The article was published on 01 Dec 2017.
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Citations
Feasibility of online radial magnetic resonance imaging for adaptive radiotherapy of pancreatic tumors.
Guus Grimbergen,H. Eijkelenkamp,Jonna K. van Vulpen,S. van de Ven,Bas W. Raaymakers,Martijn Intven,Gert J. Meijer +6 more
TL;DR: In this paper , the authors investigated the use of two motion-robust radial MRI sequences as main delineation scan for pancreatic MR-guided radiotherapy, and found that the 3D T2w scans sometimes contained a large interslice variation which would have compromised delineation.
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Intrafraction organ movement in adaptive MR-guided radiotherapy of abdominal lesions – dosimetric impact and how to detect its extent in advance
Carolin Buchele,C. Katharina Renkamp,Sebastian Regnery,Rouven Behnisch,Carolin Rippke,Fabian Schlüter,Philipp Hoegen-Saßmannshausen,Jürgen Debus,Juliane Hörner‐Rieber,M. Alber,Sebastian Klüter +10 more
TL;DR: Intrafraction organ movement significantly impacts dose distributions and OAR dose increase. It can be predicted using simulation images and potentially compensated for by adding margins to OARs.
Acceptance, commissioning and quality assurance of the MRIdian®: Site experience and three years follow-up.
TL;DR: In this article , the authors present the methodology and results of the acceptance and periodical quality controls on the MRIdian®, and investigate the impact of the magnetic field on other machines by controlling nearby linacs dose profiles.
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Optimizing patient selection for stereotactic ablative radiotherapy in patients with locally advanced pancreatic cancer after initial chemotherapy - a single center prospective cohort
Deesje Doppenberg,Frank J. Lagerwaard,Susan van Dieren,Martijn R. Meijerink,J. Van der Vliet,M.G. Besselink,Geertjan van Tienhoven,Eva Versteijne,Bjlcr Slotman,J. Wilmink,Geert Kazemier,Anna M.E. Bruynzeel +11 more
TL;DR: The role of stereotactic ablative radiation therapy (SABR) as local treatment option after chemotherapy for locally advanced pancreatic cancer (LAPC) is evolving as discussed by the authors .
Current State and Future Directions of Radiation Therapy for Pancreas Adenocarcinoma.
TL;DR: In this paper , the authors suggest select patients from across the pancreatic adenocarcinoma (PDAC) disease spectrum may benefit from adding radiation therapy (RT) to multi-modality care.
2
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TL;DR: The maximum tolerated doses of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors and brain metastases were defined for this population of patients as 24 Gy, 18 Gy, and 15 Gy for tumors, whereas investigators' reluctance to escalate to 27 Gy, rather than excessive toxicity, determined the maximum tolerated dose.
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TL;DR: It is feasible to deliver stereotactic radiosurgery to patients with locally advanced pancreatic cancer and the recommended dose to achieve local control without significant acute gastrointestinal toxicity is 25 Gy.
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Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer
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Online Magnetic Resonance Image Guided Adaptive Radiation Therapy: First Clinical Applications
Sahaja Acharya,Benjamin W. Fischer-Valuck,Rojano Kashani,Parag J. Parikh,Deshan Yang,Tianyu Zhao,Olga Green,O. Wooten,H. Harold Li,Yanle Hu,Vivian Rodriguez,L. Olsen,Clifford G. Robinson,Jeff M. Michalski,Sasa Mutic,Jeffrey R. Olsen +15 more
TL;DR: Online adaptive MR-IGRT has been successfully implemented with planning and QA workflow suitable for routine clinical application and reported of the initial clinical experience and workflow considerations.
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Stereotactic Body Radiotherapy and Gemcitabine for Locally Advanced Pancreatic Cancer
Anand Mahadevan,Sanjay Jain,Michael Goldstein,Rebecca A. Miksad,Douglas K. Pleskow,Mandeep S. Sawhney,Darren D. Brennan,Mark P. Callery,Charles M. Vollmer +8 more
TL;DR: Hypofractionated SBRT can be delivered quickly and effectively in patients with nonmetastatic, locally advanced, unresectable pancreatic cancer with acceptable side effects and minimal interference with gemcitabine chemotherapy.
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