Open Access
Factors regulating thymic dendritic cell homeostasis and function
Nicholas Spidale
- 01 Aug 2014
About: The article was published on 01 Aug 2014. and is currently open access. The article focuses on the topics: Dendritic cell homeostasis.
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Citations
•Journal Article
T cell development and the CD4-CD8 lineage decision
TL;DR: In this paper, the lineage-specific differentiation of immature CD4+CD8+ T cells into CD4 or CD8+ mature T cells is investigated, and two models were proposed initially to explain this remarkable outcome: instruction of lineage choice by initial signalling events or selection after a stochastic fate decision that limits further development to cells with coordinated TCR and co-receptor specificities.
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References
Peptide-Specific Intercellular Transfer of MHC Class II to CD4+ T Cells Directly from the Immunological Synapse upon Cellular Dissociation
TL;DR: The transfer of membrane proteins from APC to T cells is peptide specific and requires direct TCR-MHC:peptide interactions and is augmented by costimulation through CD28-CD80 interactions.
The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator
Yu Hikosaka,Takeshi Nitta,Izumi Ohigashi,Kouta Yano,Naozumi Ishimaru,Yoshio Hayashi,Mitsuru Matsumoto,Koichi Matsuo,Josef M. Penninger,Hiroshi Takayanagi,Yoshifumi Yokota,Hisakata Yamada,Yasunobu Yoshikai,Jun-ichiro Inoue,Taishin Akiyama,Yousuke Takahama +15 more
TL;DR: Results indicate that RANKL produced by positively selected thymocytes is responsible for fostering thymic medulla formation, thereby establishing central tolerance.
Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo
TL;DR: I-E expression on thymic DC is sufficient to negatively select I-E reactive CD4+ T cells, and to a less complete extent, CD8+ T Cells, and it is reported that negative, but not positive, selection events can be induced by DC in vivo.
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
Yu Lei,Yu Lei,Adiratna Mat Ripen,Naozumi Ishimaru,Izumi Ohigashi,Takashi Nagasawa,Lukas T. Jeker,Michael R. Bösl,Georg A. Holländer,Yoshio Hayashi,Rene De Waal Malefyt,Takeshi Nitta,Yousuke Takahama +12 more
TL;DR: Aire regulates medullary epithelial cell production of XCL1, a chemoattractant for XCR1-expressing thymic DCs whose presence in the medulla contributes to the generation of T reg cells.
RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
Simona W. Rossi,Mi-Yeon Kim,Andreas Leibbrandt,Sonia M. Parnell,William E. Jenkinson,Stephanie H. Glanville,Fiona M. McConnell,Hamish S. Scott,Josef M. Penninger,Eric J. Jenkinson,Peter J. L. Lane,Graham Anderson +11 more
TL;DR: A novel role for a CD4+3− inducer cell population, previously linked to development of organized secondary lymphoid structures and maintenance of T cell memory in the functional regulation of Aire-mediated promiscuous gene expression in the thymus, is demonstrated.