Open Access
Factors regulating thymic dendritic cell homeostasis and function
Nicholas Spidale
- 01 Aug 2014
About: The article was published on 01 Aug 2014. and is currently open access. The article focuses on the topics: Dendritic cell homeostasis.
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Citations
•Journal Article
T cell development and the CD4-CD8 lineage decision
TL;DR: In this paper, the lineage-specific differentiation of immature CD4+CD8+ T cells into CD4 or CD8+ mature T cells is investigated, and two models were proposed initially to explain this remarkable outcome: instruction of lineage choice by initial signalling events or selection after a stochastic fate decision that limits further development to cells with coordinated TCR and co-receptor specificities.
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Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions.
Anne L. Fletcher,Veronika Lukacs-Kornek,Erika D. Reynoso,S. Pinner,A. Bellemare-Pelletier,M. Curry,Ai-Ris Collier,Richard L. Boyd,Shannon J. Turley +8 more
TL;DR: Data show that diverse stromal cell types have evolved to constitutively express PTAs, and that exposure to viral products alters the interaction between T cells and LNSCs.
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TL;DR: This review summarizes the current knowledge about the immunoregulatory role of immature DC that might act as guardians for the induction and maintenance of T cell tolerance in the periphery.
Inhibitory Effects of Apoptotic Cell Ingestion upon Endotoxin-Driven Myeloid Dendritic Cell Maturation
TL;DR: The ingestion of apoptotic cells is not an immunologically null event but is capable of modulating DC maturation, having important implications for the understanding of the role of clearance of dying cells by DCs not only in the normal resolution of inflammation but also in control of subsequent immune responses to apoptotic cell-derived Ags.
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TL;DR: The results indicate a previously unrecognized role for ligand binding to SR-A in up-regulatingSR-A expression and activating p38 MAPK, which may modulate inflammatory responses by enhancing macrophage uptake of modified protein/lipid, bacteria, and cell debris and regulating the production of inflammatory cytokines, growth factors, and proteolytic enzymes.
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