Open Access
Factors regulating thymic dendritic cell homeostasis and function
Nicholas Spidale
- 01 Aug 2014
About: The article was published on 01 Aug 2014. and is currently open access. The article focuses on the topics: Dendritic cell homeostasis.
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Citations
•Journal Article
T cell development and the CD4-CD8 lineage decision
TL;DR: In this paper, the lineage-specific differentiation of immature CD4+CD8+ T cells into CD4 or CD8+ mature T cells is investigated, and two models were proposed initially to explain this remarkable outcome: instruction of lineage choice by initial signalling events or selection after a stochastic fate decision that limits further development to cells with coordinated TCR and co-receptor specificities.
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References
Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection
TL;DR: This paper characterizes the development and antigen-presenting function of a poorly understood population of B cells within the thymus and shows that autoreactive thymic B cells serve as efficient antigen- presenting cells for T cell negative selection even when they are present at low frequencies.
105
How thymic antigen presenting cells sample the body's self-antigens
Jens Derbinski,Bruno Kyewski +1 more
TL;DR: The combinatorial expression patterns of these attributes in distinct APC subsets result in a self-peptide display partly unique to the cortex mediating positive selection and to the medulla mediating tolerance induction.
100
Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: demonstration by differential importation of hematogenous precursors under steady state conditions.
TL;DR: The results indicate that two developmentally distinct populations of DC precursors normally enter the adult mouse thymus, implying functional heterogeneity consistent with evidence implicating lymphoid DCs in the negative selection of effector thymocytes and myeloid DCS in the positive selection of regulatory thymocyte-poor blood samples.
T-cell receptor affinity in thymic development
Amy E. Moran,Kristin A. Hogquist +1 more
TL;DR: Increasing evidence suggests that the ‘altered peptide’ model of the 1980s together with the affinity model might best explain how the thymus supports conventional and regulatory T‐cell development.
95
Developmentally Regulated Availability of RANKL and CD40 Ligand Reveals Distinct Mechanisms of Fetal and Adult Cross-Talk in the Thymus Medulla
Guillaume E. Desanti,Jennifer E. Cowan,Song Baik,Sonia M. Parnell,Andrea J. White,Josef M. Penninger,Peter J. L. Lane,Eric J. Jenkinson,William E. Jenkinson,Graham Anderson +9 more
TL;DR: It is shown how multiple hemopoietic cell types regulate mTEC development through differential provision of RANKL/CD40L during ontogeny, revealing molecular differences in fetal and adult hemopOietic cross-talk.