Journal Article10.1097/ICB.0B013E3181E17F8C
Extraocular seeding of choroidal melanoma after a transretinal biopsy with a 25-gauge vitrector
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TL;DR: A 74-year-old man with a choroidal melanoma in the left eye underwent a 3-port transconjunctival 25-gauge transretinal biopsy followed by proton beam radiotherapy and presented 14 months later with two pigmented conjunctival lesions corresponding to the site of the pars plana sclerotomy.
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Abstract: PURPOSE To report an isolated case of extraocular seeding of choroidal melanoma after a transretinal biopsy. METHODS A 74-year-old man with a choroidal melanoma in the left eye underwent a 3-port transconjunctival 25-gauge transretinal biopsy (for cytogenetic prognostication) followed by proton beam radiotherapy. Biopsy showed the melanoma to be predominantly of spindle cell type with chromosome 3 loss. He presented 14 months later with two pigmented conjunctival lesions, corresponding to the site of the pars plana sclerotomy. RESULTS Excision biopsy of the conjunctival lesions confirmed subconjunctival seeding of melanoma cells at the sites of sclerotomy. CONCLUSION The seeding of melanoma corresponded to the sites of sclerotomy, indicating extraocular seeding of the primary tumor after transretinal biopsy. We discuss the possible reasons for this occurrence and strategies to prevent extraocular seeding of melanoma after transretinal biopsy.
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Ocular treatment of choroidal melanoma in relation to the prevention of metastatic death - A personal view.
TL;DR: About 50% of patients with choroidal melanoma develop metastatic disease, despite successful eradication of the primary tumor, and patient care is complicated by the fact that the authors do not know whether ocular treatment ever influences survival and if so in whom.
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Uveal Melanoma Biopsy: A Review.
Luisa Frizziero,Edoardo Midena,Sara Trainiti,Davide Londei,Laura Bonaldi,Silvia Bini,Raffaele Parrozzani +6 more
TL;DR: The role of uveal melanoma biopsy in ophthalmic oncology is critically evaluated to critically evaluate the indications and contraindications for tumor biopsy continue to be under debate.
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Molecular prognostics for uveal melanoma.
TL;DR: There are myriad laboratory methods for prognostic analysis of uveal melanoma tissue, including a gene expression profiling test which has been validated directly through a large, prospective multicenter study and a DNA-based test which uses laboratory methods supported by extensive historical data.
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Uveal Melanoma Cell Seeding after Transretinal Tumor Biopsy
TL;DR: Transretinal tumor biopsy is of high diagnostic and prognostic value in the management of uveal lesions, but also bears the potential risk for tumor cell seeding.
References
Tumor doubling times in metastatic malignant melanoma of the uvea: tumor progression before and after treatment.
TL;DR: Current chemoimmunotherapy regimens slow down the growth rate of metastases even if objective response is not obtained, and a rational follow-up interval to detect metastatic uveal melanoma would be 4 to 6 months.
386
Fine-needle Aspiration Biopsy of Suspected Intraocular Tumors: The 1992 Urwick Lecture
TL;DR: In this paper, fine-needle aspiration biopsy was performed on selected patients who had intraocular lesions that were suspected clinically to be neoplasms but in which there was diagnostic uncertainty based on noninvasive clinical evaluation.
268
Endoresection of choroidal melanoma
TL;DR: Depending on tumour location, endoresection may conserve central vision or temporal field when radiotherapy would be expected to cause optic neuropathy, and longer follow up is necessary to establish the efficacy of tumour control.
169
Chromosome 3 Analysis of Uveal Melanoma Using Fine-Needle Aspiration Biopsy at the Time of Plaque Radiotherapy in 140 Consecutive Cases: The Deborah Iverson, MD, Lectureship
Carol L. Shields,Arupa Ganguly,Miguel A. Materin,Luiz F. Teixeira,Arman Mashayekhi,Lori Ann Swanson,Brian P. Marr,Jerry A. Shields +7 more
TL;DR: It is found that in most cases, FNAB provides adequate DNA for genetic analysis of uveal melanoma using microsatellite assay.
121
Quantitation of Tumor Seeding From Fine Needle Aspiration of Ocular Melanomas
TL;DR: While 14 of 21 (67%) of all fine needle aspiration tracts and eight of 15 (53%) of indirect tracts contained tumor cells, the number of tumor cells was less than that associated with tumor growth in experimental models.
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