Journal Article10.1182/BLOOD.V99.4.1273
Expression of type 1 (interferon gamma) and type 2 (interleukin-13, interleukin-5) cytokines at distinct stages of natural killer cell differentiation from progenitor cells.
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TL;DR: Ability to produce the type 2 cytokines IL-13 and IL-5 defines CD161(+) NK cells at intermediate stages of differentiation, and is lost upon terminal functional differentiation, concomitant with acquired ability to produce IFN-gamma.
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About: This article is published in Blood. The article was published on 15 Feb 2002. The article focuses on the topics: Interleukin 12 & Interleukin 21.
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Citations
Natural killer cells in atopic and autoimmune diseases of the skin
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IL-25 in allergic inflammation
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TL;DR: Data strongly suggest that the same molecule mediates these three activities, although the presence of traces of contaminant peptides even in the most purified NKSF preparations does not allow us to exclude the possibility that distinct biologically active molecules have been co-purified.
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Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
Kenneth H. Grabstein,June R. Eisenman,Kurt D. Shanebeck,Charles Rauch,Subhashini Srinivasan,Victor Fung,Courtney Beers,Jane S. Richardson,Michael A. Schoenborn,Minoo Ahdieh,Lisabeth Johnson,Mark R. Alderson,James D. Watson,Dirk M. Anderson,Judith G. Giri +14 more
TL;DR: A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated, indicating that IL-15 uses components of the IL-2 receptor.
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Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.
J. G. Giri,M Ahdieh,J Eisenman,K. Shanebeck,K H Grabstein,S Kumaki,A Namen,L S Park,David Cosman,Dirk M. Anderson +9 more
TL;DR: IL‐15 utilizes the common IL‐2R gamma subunit found to be defective in X‐linked severe combined immunodeficiency in humans, and is the only cytokine other thanIL‐2 that has also been shown to share the beta signaling subunit of IL‐ 2R.
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IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses
Jeanne Magram,Suzanne E. Connaughton,Rajeev R. Warrier,Daisy Carvajal,Chang-You Wu,Jessica Ferrante,Colin L. Stewart,Ulla Sarmiento,Denise A. Faherty,Maurice K. Gately +9 more
TL;DR: It is indicated that IL-12 plays an essential role in regulating IFNγ production and in facilitating normal DTH responses and other phenomena associated with Th1 responses and cell-mediated immunity, i.e., IL-2 secretion and CTL generation, were not compromised in the absence of IL- 12.
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