Open Access
Expression of RB1CC1, a novel tumor suppressor gene, is inversely correlated with the Ki-67 proliferation index in primary breast cancers
Koji Teramoto,Tokuhiro Chano,Yoshitomo Ozaki,Satoru Sawai,Keiichi Kontani,Shozo Fujino,Hidetoshi Okabe +6 more
- 01 Jan 2003
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TL;DR: A loss of RB1CC1 was significantly correlated with a high Ki-67 index and low ER status, and its prognostic value should to be established.
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Abstract: Summary Retinoblastoma 1 (RB1)-inducible coiled-coil 1 (RB1CC1) is a key regulator of RB1, and is frequently mutated in breast cancer. We examined RB1CC1 expression using immunohistochemical means and compared it with RB1 and Ki-67 labeling indices as well as estrogen receptor (ER) status in 54 primary breast cancers. RB1CC1 protein expression was absent in 8 cancers (15%), and RB1 protein was significantly decreased or absent in all of the cases lacking RB1CC1. These 8 cases showed no loss of heterozygosit y (LOH) at the RB1 locus. Importantly, a loss of RB1CC1 was significantly correlated with a high Ki-67 index (p < 0.0001) and low ER status (p = 0.0123). RB1CC1 expression predicts tumor progression, and its prognostic value should to be established.
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Citations
RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases
TL;DR: It is suggested that RB1CC1 insufficiency may result in mTOR signaling repression through unbalanced TSC1 abundance and may induce neuronal atrophy, which may have implications for the pathogenesis of Alzheimer's disease.
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Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation.
Tokuhiro Chano,Masashi Saji,Hirokazu Inoue,Kahori Minami,Toshiyuki Kobayashi,Okio Hino,Hidetoshi Okabe +6 more
TL;DR: RB1CC1 preserved cell size without cell cycle progression especially in neuromuscular tissues, and the abundance contributed to the non-proliferating enlarged cell phenotype, suggesting that RB1CC 1 is required to maintain both RB1 expression and mTOR activity.
Expression and regulation of RB1CC1 in developing murine and human tissues.
TL;DR: It is suggested that more Rb1cc1 is expressed throughout developing murine than in human tissues, and that RB1CC1 expression is controlled more stringently by modification at intron 1 in humans than in mice.
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