Open AccessJournal Article
[Expression of c-erbB2 protein and its relation to prognosis in 284 primary breast cancer patients].
Li-fang Yang,Santai Song,Xiao-bing Li,Zefei Jiang,Xiao-qing Liu,Wei-na Ma,Xi-ping Jiao,Si-qi Guo +7 more
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TL;DR: Zhang et al. as discussed by the authors investigated the expression of oncoprotein c-erbB2 in primary breast cancer and analyzed its relation to its prognosis using immunohistochemical staining.
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Abstract: Objective To investigate the expression of oncoprotein c-erbB2 in primary breast cancer and to analyze its relation to its prognosis Methods Immunohistochemical staining for c-erbB2 was performed on paraffin-embedded specimens of primary breast cancer from 284 patients, and the relation to its prognosis was statistically analyzed Results Positive expression rate of c-erbB2 was 268% （76/284） in 284 primary breast cancer patients Expression of c-erbB2 was positively correlated with the status of lymph node metastasis （P = 0 003 ） Univariate analysis indicated that c-erbB2 expression is a significant prognostic factor for the disease-free survival （DFS） （ P = 0024 ） and overall survival （OS） （ P = 0002）, while multivariate analysis demonstrated that c-erhB2 is an independent prognostic factor for OS （P = 0 023） Moreover, tumors with c-erbB2 positive expression are more tend to metastasis to other viscera than those with c-erbB2 negative, c-erbB2 expression has different prognostic values for patients with different status of estrogen receptor （ER） and lymph node metastasis Conclusion c-erbB2 expression is an independent prognostic factor for total survival time in primary breast cancer patients, and its prognostic values are different according to the different ER status and lymph node metastasis
Key words:
c-erbB2 ; Breast neoplasms; Prognosis
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The way to precision medicine of our team.
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Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases
TL;DR: Amac: Aksiller lenf nodu metastazli invaziv duktal meme karsinomda E-cadherin, p53 tumor supressor gen, c-erbB-2, ER ve PgR antikorlari degerlendirildi ekspresyonu arasindaki iliskiyi arastirmak amaclanmistir.
References
The way to precision medicine of our team.
TL;DR: Through retrospect the research and clinical achievement of the team in the past three decades, the experience and exertion on the exploration of a road to BC precision medicine are shared and a prospect of the future development direction of research and treatment is made.
Characterization of metastasis-associated cell surface glycoproteins in prostate cancer
Lifang Yang
- 01 Jan 2010
TL;DR: It was found that metastatic potentials of PC3 variants were inversely correlated with cell surface oc2-6 sialic acid levels, and a new glycoproteomic approach was successfully developed, which combined selective metabolic labeling of cell surface sialyl glycans and chemically probing the labeled sugar with a biotin tag.
Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases
TL;DR: Amac: Aksiller lenf nodu metastazli invaziv duktal meme karsinomda E-cadherin, p53 tumor supressor gen, c-erbB-2, ER ve PgR antikorlari degerlendirildi ekspresyonu arasindaki iliskiyi arastirmak amaclanmistir.